The Dorsal Root Ganglia (DRG) are a collection of cell bodies of different primary afferent neurons, which lie between vertebrae. Each is surrounded by a layer of satellite glia and resident and infiltrating cells of immune, stromal, endothelial, and other origins. Therefore, the DRG plays a significant role during pain as peripheral nerve injury can cause transcriptional reprogramming of neurons and cells in the DRG. Furthermore, changes in transcriptomic profiles of DRG neurons are associated with cancer and cancer pain. As a result, the DRG may be considered a viable therapeutic target for pain relief and differences between sexes should be studied.
In this Research Topic, Frontiers in Molecular Neuroscience – Pain Mechanisms and Modulators is looking to address key aspects of transcriptional changes in the dorsal root ganglia in order to promote the discussion around this topic and to facilitate knowledge dissemination.
We particularly welcome submission of Original Research, Review, Methods, and Perspective articles on the following sub-topics:
• Changes in transcriptomic profiles in the DRG neurons during pain
• Transcriptional reprogramming of cells in the DRG following nerve injury
• Sex differences in transcriptional changes to the DRG
• The DRG as a viable therapeutic target for pain relief
The Dorsal Root Ganglia (DRG) are a collection of cell bodies of different primary afferent neurons, which lie between vertebrae. Each is surrounded by a layer of satellite glia and resident and infiltrating cells of immune, stromal, endothelial, and other origins. Therefore, the DRG plays a significant role during pain as peripheral nerve injury can cause transcriptional reprogramming of neurons and cells in the DRG. Furthermore, changes in transcriptomic profiles of DRG neurons are associated with cancer and cancer pain. As a result, the DRG may be considered a viable therapeutic target for pain relief and differences between sexes should be studied.
In this Research Topic, Frontiers in Molecular Neuroscience – Pain Mechanisms and Modulators is looking to address key aspects of transcriptional changes in the dorsal root ganglia in order to promote the discussion around this topic and to facilitate knowledge dissemination.
We particularly welcome submission of Original Research, Review, Methods, and Perspective articles on the following sub-topics:
• Changes in transcriptomic profiles in the DRG neurons during pain
• Transcriptional reprogramming of cells in the DRG following nerve injury
• Sex differences in transcriptional changes to the DRG
• The DRG as a viable therapeutic target for pain relief