Enzymes are a class of substances having specific catalytic functions, including protein, DNA (DNAzyme), RNA (ribozyme), and some nanomaterials with catalytic activity (nanozyme). Various enzymes in the human body participate in major pathological processes, such as cancer, and have been serving as diagnostic biomarkers or therapeutic targets. In addition, enzymes also have served as a tool to improve the performance of diagnosis and therapy. For instance, some enzymes are used to amplify the target genes or detection signals, thereby improving the sensitivity of molecular diagnosis. And, some enzymes are applied to construct imaging probes or drug carriers that can specifically respond to the tumor microenvironment, thereby providing a higher signal-to-noise ratio, better treatment efficacy, or reduced side effect. With the development of enzyme screening and manual construction technology, enzymes will have a broader application prospect in the field of theranostics.
As an important component involved in many physiological and pathological processes, some enzymes' mechanisms are still unclear. Research efforts are encouraged to clarify the function of the enzyme in pathology and its reliability as a disease marker or therapeutic target. Moreover, as an essential component to boost disease diagnosis and therapy, enzyme possesses a lot of potential worth exploiting. Proposing novel enzyme-based theranostic strategies could bring forth the development of precision diagnosis and therapy. In addition, the screening and construction of novel enzymes is an important routine to broaden the application capacity of enzymes, which is also encouraged in this Research Topic.
This Research Topic aims to provide and share new ideas and technology involved in enzyme or enzyme mimics for precise diagnosis and therapy. We welcome Original Research and Review articles focusing on, but not limited to the following aspects:
• Research progress on enzyme as potential biomarker or therapy target. (The discussion on pathological mechanisms of enzymes is encouraged).
• Novel enzyme or enzyme mimics with the transcendental catalytic ability.
• Novel enzyme-assisted molecular diagnosis technology.
• Novel enzyme-activated imaging probe.
• Smart enzyme-assisted drug delivery system.
• Novel enzyme screening or construction technology.
Enzymes are a class of substances having specific catalytic functions, including protein, DNA (DNAzyme), RNA (ribozyme), and some nanomaterials with catalytic activity (nanozyme). Various enzymes in the human body participate in major pathological processes, such as cancer, and have been serving as diagnostic biomarkers or therapeutic targets. In addition, enzymes also have served as a tool to improve the performance of diagnosis and therapy. For instance, some enzymes are used to amplify the target genes or detection signals, thereby improving the sensitivity of molecular diagnosis. And, some enzymes are applied to construct imaging probes or drug carriers that can specifically respond to the tumor microenvironment, thereby providing a higher signal-to-noise ratio, better treatment efficacy, or reduced side effect. With the development of enzyme screening and manual construction technology, enzymes will have a broader application prospect in the field of theranostics.
As an important component involved in many physiological and pathological processes, some enzymes' mechanisms are still unclear. Research efforts are encouraged to clarify the function of the enzyme in pathology and its reliability as a disease marker or therapeutic target. Moreover, as an essential component to boost disease diagnosis and therapy, enzyme possesses a lot of potential worth exploiting. Proposing novel enzyme-based theranostic strategies could bring forth the development of precision diagnosis and therapy. In addition, the screening and construction of novel enzymes is an important routine to broaden the application capacity of enzymes, which is also encouraged in this Research Topic.
This Research Topic aims to provide and share new ideas and technology involved in enzyme or enzyme mimics for precise diagnosis and therapy. We welcome Original Research and Review articles focusing on, but not limited to the following aspects:
• Research progress on enzyme as potential biomarker or therapy target. (The discussion on pathological mechanisms of enzymes is encouraged).
• Novel enzyme or enzyme mimics with the transcendental catalytic ability.
• Novel enzyme-assisted molecular diagnosis technology.
• Novel enzyme-activated imaging probe.
• Smart enzyme-assisted drug delivery system.
• Novel enzyme screening or construction technology.