Cancer remains among the major leading causes of mortality since effective therapies have not emerged in many cancers. Systemic cytotoxic therapies offer a minimal survival benefit, and the field is awaiting alternative therapeutic approaches. Relative hypervascularity within solid tumors causes a hypoxic and austere microenvironment. As a result, oxygen and nutrient deprivation promote reactive oxygen species (ROS) production. In addition, local chemotherapeutic agents are also a potential source of ROS production. While sub-lethal levels of ROS have pro-tumor properties, the excess ROS levels can threaten cancer growth and survival. Therefore, cancer cell survival relies on mechanisms that mitigate excessive ROS levels when cells face these challenges.
The processes of maintaining redox balance could represent a vulnerability in cancer cells, and these can be potentially targeted therapeutically. This research topic aims to publish the underlying metabolic changes ensuring redox balance in cancer cells under oxidative stress.
The scope of this research topic covers the studies offering new insights into cancer metabolism-based redox control, cross-talk between redox signaling and metabolic pathways, and developing new therapeutic opportunities. We would like to welcome the submission of the research article, brief research, and review articles.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Cancer remains among the major leading causes of mortality since effective therapies have not emerged in many cancers. Systemic cytotoxic therapies offer a minimal survival benefit, and the field is awaiting alternative therapeutic approaches. Relative hypervascularity within solid tumors causes a hypoxic and austere microenvironment. As a result, oxygen and nutrient deprivation promote reactive oxygen species (ROS) production. In addition, local chemotherapeutic agents are also a potential source of ROS production. While sub-lethal levels of ROS have pro-tumor properties, the excess ROS levels can threaten cancer growth and survival. Therefore, cancer cell survival relies on mechanisms that mitigate excessive ROS levels when cells face these challenges.
The processes of maintaining redox balance could represent a vulnerability in cancer cells, and these can be potentially targeted therapeutically. This research topic aims to publish the underlying metabolic changes ensuring redox balance in cancer cells under oxidative stress.
The scope of this research topic covers the studies offering new insights into cancer metabolism-based redox control, cross-talk between redox signaling and metabolic pathways, and developing new therapeutic opportunities. We would like to welcome the submission of the research article, brief research, and review articles.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
