Control strategies against ruminant infectious diseases are an important issue not only for the economic impact of infections on food production but also on public health. Vaccination of ruminants improves animal health and productivity and also has a significant impact on public health through reduction in the use of veterinary pharmaceuticals, especially antimicrobials, with the potential of decreasing the emergence of antimicrobial-resistant pathogens (AMR). Also, vaccines could reduce the presence of drug-residues in the human food chain, and prevent or reduce diseases caused by AMR. In addition, vaccines against zoonotic or food-borne infections are aimed at reducing or eliminating the risk for humans. Currently, numerous live attenuated and inactivated vaccines (so called conventional vaccines) are available for ruminant pathogens.
Most conventional veterinary vaccines were designed empirically. However, depending on the aim of vaccination (prevention/reduction of clinical signs of the disease after infection, reduction of dissemination of the pathogen after infection, control, elimination or eradication of an infection), vaccine effectiveness and mechanism of action may vary. The development of rationally design vaccines that achieve a required outcome needs an integrated analysis of the protective immune response required for each pathogen and the understanding of the mechanisms underlying efficacy of novel vaccines. New technologies applied on different research areas covering pathogenesis of infectious disease, development of new adjuvants or nanovesicles, and systems vaccinology studies, will create an amount of data extremely useful to suggest the better vaccination strategy for each ruminant species and pathogen.
In this context, for this Research Topic we welcome studies related to the development and evaluation of rationally designed vaccines against ruminant pathogens. We invite submissions of Original Research, Reviews and Mini-Reviews focusing on but not limited to:
- Viral vectored vaccines
- Systems vaccinology studies for ruminant vaccines
- Advances in vaccines delivery systems (including distribution and routes of administration)
- Reverse engineering and novel strategies for antigen selection for ruminant´s vaccines
- Vaccination strategies to improve host immune response against pathogens
- Development of in vitro or animal models to test vaccine safety and efficacy
- Advances in adjuvants and nanovehicles for ruminant vaccines
Control strategies against ruminant infectious diseases are an important issue not only for the economic impact of infections on food production but also on public health. Vaccination of ruminants improves animal health and productivity and also has a significant impact on public health through reduction in the use of veterinary pharmaceuticals, especially antimicrobials, with the potential of decreasing the emergence of antimicrobial-resistant pathogens (AMR). Also, vaccines could reduce the presence of drug-residues in the human food chain, and prevent or reduce diseases caused by AMR. In addition, vaccines against zoonotic or food-borne infections are aimed at reducing or eliminating the risk for humans. Currently, numerous live attenuated and inactivated vaccines (so called conventional vaccines) are available for ruminant pathogens.
Most conventional veterinary vaccines were designed empirically. However, depending on the aim of vaccination (prevention/reduction of clinical signs of the disease after infection, reduction of dissemination of the pathogen after infection, control, elimination or eradication of an infection), vaccine effectiveness and mechanism of action may vary. The development of rationally design vaccines that achieve a required outcome needs an integrated analysis of the protective immune response required for each pathogen and the understanding of the mechanisms underlying efficacy of novel vaccines. New technologies applied on different research areas covering pathogenesis of infectious disease, development of new adjuvants or nanovesicles, and systems vaccinology studies, will create an amount of data extremely useful to suggest the better vaccination strategy for each ruminant species and pathogen.
In this context, for this Research Topic we welcome studies related to the development and evaluation of rationally designed vaccines against ruminant pathogens. We invite submissions of Original Research, Reviews and Mini-Reviews focusing on but not limited to:
- Viral vectored vaccines
- Systems vaccinology studies for ruminant vaccines
- Advances in vaccines delivery systems (including distribution and routes of administration)
- Reverse engineering and novel strategies for antigen selection for ruminant´s vaccines
- Vaccination strategies to improve host immune response against pathogens
- Development of in vitro or animal models to test vaccine safety and efficacy
- Advances in adjuvants and nanovehicles for ruminant vaccines