Myeloid-derived suppressor cell (MDSC)-induced immunologic dissonance is a major cause of different diseases, such as cancer and autoimmune disease. The cell biology of MDSCs is tightly modulated by a complicated pathway network, in which epigenetic regulators are involved. Epigenetic modification represents the phenomenon of phenotype change in the absence of genotype change, which contains stable and transient structural changes of chromatin regions for registration, signaling, or perpetuating altered activity states. Although it has been widely identified that epigenetic modification (including DNA methylation, histone modification, nucleosome remodeling, and ncRNAs) induces the changes in MDSC differentiation and function, the accurate regulatory mechanisms are still incompletely understood.
The goal of this Research Topic is to provide a forum to advance research on the accurate mechanisms that epigenetic modifications induce the changes in MDSC biology, as well as explore the clinical application prospect of epigenetic therapy targeting MDSCs in individuals with cancer or autoimmune disease. We welcome manuscripts from the following subtopics:
• Mechanisms of epigenetic modifications induce the changes in MDSC differentiation and function
• Clinical applications of epigenetic therapy targeting MDSCs
• Inducers of the epigenetic modification in MDSCs
• Cell biology changes of different MDSC subsets
• The influence of epigenetic modification in MDSCs on the intercellular interaction
Myeloid-derived suppressor cell (MDSC)-induced immunologic dissonance is a major cause of different diseases, such as cancer and autoimmune disease. The cell biology of MDSCs is tightly modulated by a complicated pathway network, in which epigenetic regulators are involved. Epigenetic modification represents the phenomenon of phenotype change in the absence of genotype change, which contains stable and transient structural changes of chromatin regions for registration, signaling, or perpetuating altered activity states. Although it has been widely identified that epigenetic modification (including DNA methylation, histone modification, nucleosome remodeling, and ncRNAs) induces the changes in MDSC differentiation and function, the accurate regulatory mechanisms are still incompletely understood.
The goal of this Research Topic is to provide a forum to advance research on the accurate mechanisms that epigenetic modifications induce the changes in MDSC biology, as well as explore the clinical application prospect of epigenetic therapy targeting MDSCs in individuals with cancer or autoimmune disease. We welcome manuscripts from the following subtopics:
• Mechanisms of epigenetic modifications induce the changes in MDSC differentiation and function
• Clinical applications of epigenetic therapy targeting MDSCs
• Inducers of the epigenetic modification in MDSCs
• Cell biology changes of different MDSC subsets
• The influence of epigenetic modification in MDSCs on the intercellular interaction