Bone and joint diseases, such as osteoporosis, osteoarthritis, inflammatory arthritis, bone metastasis, osteonecrosis, endemic Kashin-Beck disease, and Marfan syndrome, affect a large population worldwide and have a serious disease burden. Substantial evidence indicates that most of them are complex disorders with genetic and environmental risk factors contributing to their development and progression. The expanding awareness of different genes that play a role in the onset of the development of bone and joint diseases, together with environmental mediators thought to be associated with their pathogenesis, will help better manage these conditions.
The application of novel molecular genetic techniques or disease models provides a valuable basis for a comprehensive understanding of the etiology and pathogenesis of bone and joint diseases. In addition, elucidating the genetic and environmental contributions of these diseases will also facilitate drug selection and the development of targeted therapeutic strategies.
The goal of this Research Topic is to identify the novel components involved in diagnosis and therapy, etiology and pathogenesis, and response to environmental exposure by different approaches. These components could include proteins, various types of RNA, DNA, and metabolites. The research topic mainly focuses on bone and joint diseases, such as osteoporosis, osteoarthritis, inflammatory arthritis, bone metastasis, osteonecrosis, endemic Kashin-Beck disease, and Marfan syndrome. We hope to better understand the interactions between genetic and environmental roles in bone and joint diseases. This research topic will assemble a group of articles that could include original research, methods, and reviews to integrate multiple methods to provide a new view of genetic and environmental roles in bone and joint diseases.
This Research Topic welcomes Original Research, Brief Research Reports, Reviews, and Methods papers focused on integrating different approaches to identify the genetic and environmental role in bone and joint diseases. These could include, but are not limited to:
• Identification of novel genes involved in etiology and pathogenesis of bone and joint diseases
• Identification of potential diagnostic markers and therapeutic targets for bone and joint diseases
• Gene-environment interactions in bone and joint diseases
• In vivo/vitro models or clinical investigations that help understand the role of genetic and environmental factors in etiology and pathogenesis in bone and joint diseases
• Genetic response to environmental exposures in bone and joint diseases
Bone and joint diseases, such as osteoporosis, osteoarthritis, inflammatory arthritis, bone metastasis, osteonecrosis, endemic Kashin-Beck disease, and Marfan syndrome, affect a large population worldwide and have a serious disease burden. Substantial evidence indicates that most of them are complex disorders with genetic and environmental risk factors contributing to their development and progression. The expanding awareness of different genes that play a role in the onset of the development of bone and joint diseases, together with environmental mediators thought to be associated with their pathogenesis, will help better manage these conditions.
The application of novel molecular genetic techniques or disease models provides a valuable basis for a comprehensive understanding of the etiology and pathogenesis of bone and joint diseases. In addition, elucidating the genetic and environmental contributions of these diseases will also facilitate drug selection and the development of targeted therapeutic strategies.
The goal of this Research Topic is to identify the novel components involved in diagnosis and therapy, etiology and pathogenesis, and response to environmental exposure by different approaches. These components could include proteins, various types of RNA, DNA, and metabolites. The research topic mainly focuses on bone and joint diseases, such as osteoporosis, osteoarthritis, inflammatory arthritis, bone metastasis, osteonecrosis, endemic Kashin-Beck disease, and Marfan syndrome. We hope to better understand the interactions between genetic and environmental roles in bone and joint diseases. This research topic will assemble a group of articles that could include original research, methods, and reviews to integrate multiple methods to provide a new view of genetic and environmental roles in bone and joint diseases.
This Research Topic welcomes Original Research, Brief Research Reports, Reviews, and Methods papers focused on integrating different approaches to identify the genetic and environmental role in bone and joint diseases. These could include, but are not limited to:
• Identification of novel genes involved in etiology and pathogenesis of bone and joint diseases
• Identification of potential diagnostic markers and therapeutic targets for bone and joint diseases
• Gene-environment interactions in bone and joint diseases
• In vivo/vitro models or clinical investigations that help understand the role of genetic and environmental factors in etiology and pathogenesis in bone and joint diseases
• Genetic response to environmental exposures in bone and joint diseases