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Purpose: The present study aimed to explore the risk factors for tuberculous meningitis (TBM) among patients with tuberculosis (TB).

Methods: This retrospective study was conducted on patients with TB who were hospitalized in Beijing Chest Hospital between January 2012 and December 2019. Demographic and clinical data of patients with TB were extracted from electronic medical records using a standardized data collection system. Logistic regression was used to analyze the risk factors associated with TBM.

Results: Of the total number of 22,988 cases enrolled, 3.1% were cases of TBM, which included 127 definite and 581 probable TBM, respectively. Multivariate analysis showed that definite TBM was significantly associated with patients aged < 30 years [adjusted odds ratio (aOR) = 3.015, 95% confidence interval (CI): (1.451–6.266)], who were farmers [aOR = 1.490, 95%CI: (1.020–2.177)], with miliary pulmonary TB [aOR = 105.842, 95%CI: (71.704–156.235)], and with malnutrition [aOR = 2.466, 95%CI: (1.110–5.479)]. Additionally, probable TBM was significantly associated with patients aged < 30 years [aOR = 2.174, 95% CI: (1.450–3.261)], aged 30–59 years [aOR = 1.670, 95% CI: (1.222–2.282)], who were farmers [aOR = 1.482, 95%CI: (1.203–1.825)], with miliary pulmonary TB [aOR = 108.696, 95%CI: (87.122–135.613)], and with a digestive system TB [aOR = 2.906, 95%CI: (1.762–4.793)].

Conclusion: An age of < 30 years, being a farmer, and having miliary pulmonary TB were risk factors for TBM among patients with TB. Further screening of patients with TB with aforementioned characteristics could facilitate clinicians to identify patients with TBM at an early stage.

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Original Research
22 November 2022

Background: Tuberculosis is a communicable disease that is a major cause of ill health. Bibliometrics is an important statistical methodology used to analyze articles and other publications in the literature study. In this study, publications on molecular epidemiology were analyzed using bibliometric analysis. The statistical analysis of influential publications, journals, countries and authors was first conducted.

Methods: The Web of Science database was searched for publications on the molecular epidemiology of tuberculosis with the keywords “tuberculosis” and “molecular epidemiology” in the title. The number of publications, citation analysis, co-authorship of the author, institution and country, keyword co-occurrence, and reference co-citations were analyzed.

Results: A total of 225 journal articles were retrieved. The mean citation was 37.72 per article and 292.69 per year. The annual publications on molecular epidemiology fluctuated within a certain range in the past. Journal of Clinical Microbiology is the most published journal with 33 articles. RASTOGI N is the most prolific author with 11 articles. The top 1 research institution is Inst Pasteur Guadeloupe. Stratified by the number of publications, the USA was the most prolific country. It also cooperates closely with other countries. Burstness analysis of references and keywords showed that the developing research trends in this field mainly focused on “genetic diversity” and “lineage” during the past decade.

Conclusion: The annual publications on tuberculosis molecular epidemiology fluctuated within a specific range in the past decade. The USA continues to dominate research output and funding. The exchange of expertise, ideas, and technology is of paramount importance in this field. More frequent and deeper cooperation among countries or institutions will be essential in the future.

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Frontiers in Microbiology

Multi-Omics Research in Disease Microbiology
Edited by Chandrajit Lahiri, Chirajyoti Deb, Datta Madamwar
Deadline
30 November 2024
Submit a paper
Recommended Research Topics
Frontiers Logo

Frontiers in Microbiology

Multi-Omics Research in Disease Microbiology
Edited by Chandrajit Lahiri, Chirajyoti Deb, Datta Madamwar
Deadline
30 November 2024
Submit a paper