The current Research Topic focuses on the role of microbiome-derived metabolites in maintaining health and how alterations in these metabolites are associated with or promote the development of diseases including autoimmunity, metabolic syndrome, chronic inflammation, neurodegeneration, allergic reactions, and cancer. This issue intends to facilitate an understanding of how the various functional characteristics of metabolites impact organ systems. It also aims to understand whether different diseases can be characterized by altered ratios of metabolites in clinical samples and if these alterations could serve as a basis for the development of microbiome metabolite-based therapeutics for a wide range of diseases.
The goal of the Research Topic is to find individual or classes of microbial metabolites that are expressed differentially in multiple diseases. This would help identify common denominators that could develop into diagnostic markers and/or therapeutically targeted by adding back-selected metabolites that re-establish immunologic and/or metabolic homeostasis. Having all of this in this issue would provide the community with valuable resources with a single focus without it being scattered throughout the literature. In this way, perhaps a more holistic understanding of the potential of microbial-derived metabolites would be achieved.
The scope of the topic and themes would span the biological role(s) of microbiome-derived metabolites in health and disease. We welcome concise, state-of-the-art overviews highlighting the gaps in our understanding of the role of metabolites in health and diseases and some of the critical questions to be addressed to fill those gaps. In other words, a critical assessment of the particulars in each paper would help stimulate further progress in the field. We would also like authors to present articles that include expert perspectives in their chosen area related to this field. Please avoid articles that address differences in bacterial composition that are associated with various disease states (dysbiosis).
The current Research Topic focuses on the role of microbiome-derived metabolites in maintaining health and how alterations in these metabolites are associated with or promote the development of diseases including autoimmunity, metabolic syndrome, chronic inflammation, neurodegeneration, allergic reactions, and cancer. This issue intends to facilitate an understanding of how the various functional characteristics of metabolites impact organ systems. It also aims to understand whether different diseases can be characterized by altered ratios of metabolites in clinical samples and if these alterations could serve as a basis for the development of microbiome metabolite-based therapeutics for a wide range of diseases.
The goal of the Research Topic is to find individual or classes of microbial metabolites that are expressed differentially in multiple diseases. This would help identify common denominators that could develop into diagnostic markers and/or therapeutically targeted by adding back-selected metabolites that re-establish immunologic and/or metabolic homeostasis. Having all of this in this issue would provide the community with valuable resources with a single focus without it being scattered throughout the literature. In this way, perhaps a more holistic understanding of the potential of microbial-derived metabolites would be achieved.
The scope of the topic and themes would span the biological role(s) of microbiome-derived metabolites in health and disease. We welcome concise, state-of-the-art overviews highlighting the gaps in our understanding of the role of metabolites in health and diseases and some of the critical questions to be addressed to fill those gaps. In other words, a critical assessment of the particulars in each paper would help stimulate further progress in the field. We would also like authors to present articles that include expert perspectives in their chosen area related to this field. Please avoid articles that address differences in bacterial composition that are associated with various disease states (dysbiosis).