Over the last several years, there has been increasing recognition regarding multidisciplinary medicine. The field of neuro-gastroenterology which refers to the study of the extrinsic and intrinsic nervous system circuits controlling the gastrointestinal tract has garnered increasing attention over recent years through both epidemiologic and mechanistic studies. For example, research has shown that ß-NAD+ or one of its metabolites is the purinergic inhibitory neurotransmitter in the colon, suggesting the potential to be harnessed for the therapeutic regulation of colonic motility in patients suffering from gastrointestinal motility disorders. The Rome foundation global epidemiology study discusses the epidemiology of disorders of gut-brain interactions. Celiac disease has been linked to cerebellar ataxia, myoclonic ataxia, myelopathy, and peripheral nerve involvement. Crohn’s disease has been associated with posterior reversible encephalopathy syndrome, anterior ischemic optic neuropathy, and chronic axonal sensory and motor polyneuropathy. Colorectal adenocarcinoma has been linked to sensory neuropathy and limbic encephalitis. Gut microbial dysbiosis has been linked to enteric nervous system dysregulation and irritable bowel syndrome.
Although associations are being established regarding neurologic manifestations of gastrointestinal disease, little is known about pathophysiologic mechanisms entailing these disease processes. For examples, some data has suggested possible alterations in inflammatory pathways such as oxidative stress, immune-mediated mechanisms (cross-reacting antibodies, immune-complex deposition, T cell cytotoxicity), and nutritional deficiencies such as calcium, folic acid and vitamin b12. More recently, there has been evidence suggesting neuroinflammation triggered by gut microbiota alterations as a possible link between Crohn’s disease and some neuropsychiatric disorders. Furthermore, novel methodologies and technologies such as optogenetics, chemogenetics, and electrophysiology have been implemented to advance our understanding of these neurologic manifestations of gastrointestinal disorders.
In order to better understand neuro-gastroenterological diseases, a multidisciplinary collaboration between neurologists, gastroenterologists, physiologists, and microbiologists is paramount. A compilation of cutting-edge expertise on this Research Topic is necessary in order to effectively understand and treat patients of their neurologic ailments.
In order to better understand neuro-gastroenterologic disease, a multidisciplinary collaboration between neurologists, gastroenterologists, physiologists, and microbiologists is paramount. A compilation of cutting-edge expertise on this Research Topic is necessary in order to effectively understand and treat patients for their neurologic ailments.
In this Research Topic we would like to explore:
-Novel neurological manifestations of gastrointestinal diseases
-The epidemiology of neuro-gastroenterological disease and how an understanding of such epidemiology can help tailor therapies to patient populations affected
-Advancements in our understanding of underlying pathophysiologic mechanisms including but not limited to gut brain axis, neuroinflammation caused by gastrointestinal diseases, nutritional deficiencies, and immune-mediated mechanisms as they pertain to neurogastroenterology.
-Exploring new technologies which have been implemented to better understand neurologic manifestations of gastrointestinal diseases.
We welcome articles from both basic science and clinical research including Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, Perspective.
Over the last several years, there has been increasing recognition regarding multidisciplinary medicine. The field of neuro-gastroenterology which refers to the study of the extrinsic and intrinsic nervous system circuits controlling the gastrointestinal tract has garnered increasing attention over recent years through both epidemiologic and mechanistic studies. For example, research has shown that ß-NAD+ or one of its metabolites is the purinergic inhibitory neurotransmitter in the colon, suggesting the potential to be harnessed for the therapeutic regulation of colonic motility in patients suffering from gastrointestinal motility disorders. The Rome foundation global epidemiology study discusses the epidemiology of disorders of gut-brain interactions. Celiac disease has been linked to cerebellar ataxia, myoclonic ataxia, myelopathy, and peripheral nerve involvement. Crohn’s disease has been associated with posterior reversible encephalopathy syndrome, anterior ischemic optic neuropathy, and chronic axonal sensory and motor polyneuropathy. Colorectal adenocarcinoma has been linked to sensory neuropathy and limbic encephalitis. Gut microbial dysbiosis has been linked to enteric nervous system dysregulation and irritable bowel syndrome.
Although associations are being established regarding neurologic manifestations of gastrointestinal disease, little is known about pathophysiologic mechanisms entailing these disease processes. For examples, some data has suggested possible alterations in inflammatory pathways such as oxidative stress, immune-mediated mechanisms (cross-reacting antibodies, immune-complex deposition, T cell cytotoxicity), and nutritional deficiencies such as calcium, folic acid and vitamin b12. More recently, there has been evidence suggesting neuroinflammation triggered by gut microbiota alterations as a possible link between Crohn’s disease and some neuropsychiatric disorders. Furthermore, novel methodologies and technologies such as optogenetics, chemogenetics, and electrophysiology have been implemented to advance our understanding of these neurologic manifestations of gastrointestinal disorders.
In order to better understand neuro-gastroenterological diseases, a multidisciplinary collaboration between neurologists, gastroenterologists, physiologists, and microbiologists is paramount. A compilation of cutting-edge expertise on this Research Topic is necessary in order to effectively understand and treat patients of their neurologic ailments.
In order to better understand neuro-gastroenterologic disease, a multidisciplinary collaboration between neurologists, gastroenterologists, physiologists, and microbiologists is paramount. A compilation of cutting-edge expertise on this Research Topic is necessary in order to effectively understand and treat patients for their neurologic ailments.
In this Research Topic we would like to explore:
-Novel neurological manifestations of gastrointestinal diseases
-The epidemiology of neuro-gastroenterological disease and how an understanding of such epidemiology can help tailor therapies to patient populations affected
-Advancements in our understanding of underlying pathophysiologic mechanisms including but not limited to gut brain axis, neuroinflammation caused by gastrointestinal diseases, nutritional deficiencies, and immune-mediated mechanisms as they pertain to neurogastroenterology.
-Exploring new technologies which have been implemented to better understand neurologic manifestations of gastrointestinal diseases.
We welcome articles from both basic science and clinical research including Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, Perspective.
