G protein-coupled receptors: neuromodulation and diseases

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98

authors

16

articles

G protein-coupled receptors: neuromodulation and diseases

291.5K

views

98

authors

16

articles

Editors

1

University of Toronto

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G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane receptors that recognize a diverse array of extracellular stimuli and widely exist in the central nervous system. These receptors modulate the key neurotransmitter systems and participate in many different cellular processes that could be disrupted in human diseases. Thus, GPCRs become potential therapeutic targets for a range of neurological and psychiatric disorders.

This research topic focuses on roles of GPCRs in modulating synaptic transmission, plasticity and higher brain functions in neurological (neurodevelopmental and neurodegenerative) and psychiatric diseases. The scope of this research topic includes, but is not limited to: deficits in GPCRs and their downstream signaling pathways in disease model organisms; molecular mechanisms underlying disruption of GPCR signalings in neurological and psychiatric disorders; modulation of neurotransmitter systems and synaptic plasticity by GPCRs in disease conditions; neural and behavioral responses to potential therapeutic strategies targeting GPCRs in disease model systems and the translational relevance of those targets to patients with neurological or psychiatric disorders.

G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane receptors that recognize a diverse array of extracellular stimuli and widely exist in the central nervous system. These receptors modulate the key neurotransmitter systems and participate in many different cellular processes that could be disrupted in human diseases. Thus, GPCRs become potential therapeutic targets for a range of neurological and psychiatric disorders.

This research topic focuses on roles of GPCRs in modulating synaptic transmission, plasticity and higher brain functions in neurological (neurodevelopmental and neurodegenerative) and psychiatric diseases. The scope of this research topic includes, but is not limited to: deficits in GPCRs and their downstream signaling pathways in disease model organisms; molecular mechanisms underlying disruption of GPCR signalings in neurological and psychiatric disorders; modulation of neurotransmitter systems and synaptic plasticity by GPCRs in disease conditions; neural and behavioral responses to potential therapeutic strategies targeting GPCRs in disease model systems and the translational relevance of those targets to patients with neurological or psychiatric disorders.

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Editors

University of Toronto

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249,599 Article views

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Published In

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Frontiers in Pharmacology

Neuropharmacology

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Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

Journal Thumbnail

Frontiers in Neuroscience

Neuropharmacology

Journal Thumbnail

Frontiers in Physiology

Integrative Physiology

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Frontiers in Psychiatry

Neuropharmacology

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Frontiers in Neurology

Neuropharmacology

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