PI3K/AKT pathway is a highly conserved signaling pathway with a crucial role in the cellular response to extracellular stimuli and controlling essential activities, such as cell proliferation, apoptosis, and angiogenesis.
Aberrant activation of PI3K signaling cascades is one of the most frequent events in both solid tumors and hematological malignancies. PI3K pathway is known to be involved in cellular transformation, cell migration, and failure to activate the apoptotic program, the latter representing a major mechanism of drug resistance in tumor cells.
An increasing number of studies have been focused on the therapeutic potential of targeting the PI3K/AKT signaling cascade. However, a better understanding of the molecular mechanisms involved in the PI3K-driven cancer progression and the response to the present cancer treatments is necessary to develop innovative targeted therapies for long-term response.
In this Research Topic, we welcome studies that focus on, but not limited to:
- The interplay between current cancer treatment and the PI3K pathway
- Clinical translations of PI3K signaling-dependent targeted therapies
- Identification of members of the PI3K signaling cascade involved in tumor progression, and their potential as therapeutic targets
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
PI3K/AKT pathway is a highly conserved signaling pathway with a crucial role in the cellular response to extracellular stimuli and controlling essential activities, such as cell proliferation, apoptosis, and angiogenesis.
Aberrant activation of PI3K signaling cascades is one of the most frequent events in both solid tumors and hematological malignancies. PI3K pathway is known to be involved in cellular transformation, cell migration, and failure to activate the apoptotic program, the latter representing a major mechanism of drug resistance in tumor cells.
An increasing number of studies have been focused on the therapeutic potential of targeting the PI3K/AKT signaling cascade. However, a better understanding of the molecular mechanisms involved in the PI3K-driven cancer progression and the response to the present cancer treatments is necessary to develop innovative targeted therapies for long-term response.
In this Research Topic, we welcome studies that focus on, but not limited to:
- The interplay between current cancer treatment and the PI3K pathway
- Clinical translations of PI3K signaling-dependent targeted therapies
- Identification of members of the PI3K signaling cascade involved in tumor progression, and their potential as therapeutic targets
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.