BackgroundSeveral important milestones have been achieved in the field of biosciences thanks to the application of in vitro models, allowing scientists to develop concepts, technologies, and methodologies to better understand more complex living systems. Their use accomplish with the principle of Replacement described in the 3Rs and include a range of subject areas within basic and applied physiology. Many of these non-animal approaches (NAMs) are used in assessing chemical or drug toxicity while non-animal technologies (NATs) are used for disease modelling and efficacy as well as to develop safety and toxicity tests.
In a similar manner, research in aquatic organisms also benefits from this kind of non-animal approaches, based on the use of specific tissues, cellular types or enzymes, with a wide range of applications in toxicological, pathological and immunological studies as well as in nutrition and metabolism of different species.
GoalsThis Research Topic aims to shed light on the advantages and potentials, but also on the challenges and limitations that accompany the application of different
in vitro approaches in aquatic organisms. The collection is interested in describing physiologically based
in vitro models that can be used to assess different aspects of epithelial transport, sensitivity to toxics and pathogens in different organs, as well as gut functionality and its effect on nutrient bioavailability, among others.
Scope and information for AuthorsManuscripts submitted to this Research Topic should be in line with the
scope of the Aquatic Physiology section. Several article types will be considered, please find more information
here.
Topic Editors Dr. Hector Nolasco Soria and Dr. Francisco Javier Moyano hold two patents related to an in vitro digestion cell. Topic Editor Dr. Juan Fuentes declares no competing interests with regards to the Research Topic subject.This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:
•
Animal Models and Transgenic Technology in Craniofacial Biology•
Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges•
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges•
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications•
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research•
Model Organisms: Opportunities and Challenges in Developmental Physiology•
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research•
Model Organisms and Experimental Models: Opportunities and Challenges in Musculoskeletal Physiology•
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology•
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology•
Experimental Models of Rare Cardiac Diseases BackgroundSeveral important milestones have been achieved in the field of biosciences thanks to the application of in vitro models, allowing scientists to develop concepts, technologies, and methodologies to better understand more complex living systems. Their use accomplish with the principle of Replacement described in the 3Rs and include a range of subject areas within basic and applied physiology. Many of these non-animal approaches (NAMs) are used in assessing chemical or drug toxicity while non-animal technologies (NATs) are used for disease modelling and efficacy as well as to develop safety and toxicity tests.
In a similar manner, research in aquatic organisms also benefits from this kind of non-animal approaches, based on the use of specific tissues, cellular types or enzymes, with a wide range of applications in toxicological, pathological and immunological studies as well as in nutrition and metabolism of different species.
GoalsThis Research Topic aims to shed light on the advantages and potentials, but also on the challenges and limitations that accompany the application of different
in vitro approaches in aquatic organisms. The collection is interested in describing physiologically based
in vitro models that can be used to assess different aspects of epithelial transport, sensitivity to toxics and pathogens in different organs, as well as gut functionality and its effect on nutrient bioavailability, among others.
Scope and information for AuthorsManuscripts submitted to this Research Topic should be in line with the
scope of the Aquatic Physiology section. Several article types will be considered, please find more information
here.
Topic Editors Dr. Hector Nolasco Soria and Dr. Francisco Javier Moyano hold two patents related to an in vitro digestion cell. Topic Editor Dr. Juan Fuentes declares no competing interests with regards to the Research Topic subject.This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:
•
Animal Models and Transgenic Technology in Craniofacial Biology•
Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges•
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges•
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications•
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research•
Model Organisms: Opportunities and Challenges in Developmental Physiology•
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research•
Model Organisms and Experimental Models: Opportunities and Challenges in Musculoskeletal Physiology•
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology•
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology•
Experimental Models of Rare Cardiac Diseases