Bacterial infection, excessive inflammation, and excessive oxidative stress are widespread in the micro-environment of many infectious lesions and wounds. The problem commonly occurs during the repair of arthritis cartilage, gout, diabetic wounds, and chronically infected wounds. The main treatment for wound infections is extensive antibiotic therapy, but bacterial resistance and the emergence of biofilms severely limit the efficacy of antibiotics. To solve the excessive inflammation, excessive oxidative stress, and related long-term chronic pain, hormonal drugs and non-steroidal drugs are widely used in clinical practice. However, the damage to the gastrointestinal tract, liver, and kidney function caused by these drugs cannot be ignored. Regarding this issue, nanomaterials have been adopted to construct multifunctional nanoplatforms, aiming to alleviate the above side effects. Various candidates have been explored recently, such as metal-organic frameworks (MOFs), black phosphorus, dopamine nanoparticles, noble metal nanoclusters, nanogel, copolymer nanovesicles, exosomes, quantum dots, graphene nanomaterials, carbon nanomaterials, etc. Therefore, antibacterial, anti-inflammatory, and reactive oxygen species (ROS)-responsive drug delivery nanoplatforms are very attractive and promising for medicinal use.
The goal of this Research Topic is to explore and obtain multifunctional nanoplatform materials with antibacterial, anti-inflammatory, and oxidative stress-regulating functions, which can be applied for diabetic wound repair, arthritis cartilage repair, and other relevant circumstances. This article collection aims to shed light on the most advanced achievements in the medicinal and pharmaceutical chemistry of nanoplatform materials, which should inspire and guide the future direction of this field.
The scope of the Research Topic includes drug delivery, nanomaterials, wound healing, etc. Clinical case reports and evidence-based medicine reports do not fall within the scope of this topic. Areas to be covered in this Research Topic may include, but are not limited to:
• Novel nanoplatforms with antibacterial, anti-inflammatory, and ROS-responsive properties.
• Mechanism study and deep understanding of the drug delivery process of nanoplatforms.
• New design, synthesis, and evaluation methods of nanoplatforms with pharmaceutical function.
• Investigation of side effects of nanoplatforms for medicinal use.
Bacterial infection, excessive inflammation, and excessive oxidative stress are widespread in the micro-environment of many infectious lesions and wounds. The problem commonly occurs during the repair of arthritis cartilage, gout, diabetic wounds, and chronically infected wounds. The main treatment for wound infections is extensive antibiotic therapy, but bacterial resistance and the emergence of biofilms severely limit the efficacy of antibiotics. To solve the excessive inflammation, excessive oxidative stress, and related long-term chronic pain, hormonal drugs and non-steroidal drugs are widely used in clinical practice. However, the damage to the gastrointestinal tract, liver, and kidney function caused by these drugs cannot be ignored. Regarding this issue, nanomaterials have been adopted to construct multifunctional nanoplatforms, aiming to alleviate the above side effects. Various candidates have been explored recently, such as metal-organic frameworks (MOFs), black phosphorus, dopamine nanoparticles, noble metal nanoclusters, nanogel, copolymer nanovesicles, exosomes, quantum dots, graphene nanomaterials, carbon nanomaterials, etc. Therefore, antibacterial, anti-inflammatory, and reactive oxygen species (ROS)-responsive drug delivery nanoplatforms are very attractive and promising for medicinal use.
The goal of this Research Topic is to explore and obtain multifunctional nanoplatform materials with antibacterial, anti-inflammatory, and oxidative stress-regulating functions, which can be applied for diabetic wound repair, arthritis cartilage repair, and other relevant circumstances. This article collection aims to shed light on the most advanced achievements in the medicinal and pharmaceutical chemistry of nanoplatform materials, which should inspire and guide the future direction of this field.
The scope of the Research Topic includes drug delivery, nanomaterials, wound healing, etc. Clinical case reports and evidence-based medicine reports do not fall within the scope of this topic. Areas to be covered in this Research Topic may include, but are not limited to:
• Novel nanoplatforms with antibacterial, anti-inflammatory, and ROS-responsive properties.
• Mechanism study and deep understanding of the drug delivery process of nanoplatforms.
• New design, synthesis, and evaluation methods of nanoplatforms with pharmaceutical function.
• Investigation of side effects of nanoplatforms for medicinal use.