Bone nonunion (BN) is a refractory condition in which the body is unable to heal a fracture without medical or surgical intervention. Even after mitigating various sources of risk including inappropriate surgery, infection, malnutrition and metabolic abnormalities, a considerable number of fracture patients still suffer from BN. There are a range of different X-ray manifestations of BN, which can include atrophic, oligotrophic and hypertrophic nonunions and in chronic cases, pseudarthrosis. Once BN occurs, patients may experience disabling morbidity. This may be due to the affected limb being unable to bear weight for an extended period of time which can then threaten not only associated joints but also systemic functions. In addition, effective clinical treatments for BN are still limited with a lack of in-depth research on new therapeutic technologies.
Rapid economic and industrial developments around the world have led to increased traffic accidents and other traumatic mechanisms in recent years. Thus, the incidence of BN is also rising, leading to an increased economic burden on patients, their families, and social medical costs. Therefore, developing a efficient and effective treatment for fracture nonunion is crucial.
This Research Topic aims to shed light on the latest clinical cases and treatments for bone nonunion. We also wish to explore the basic research progress in the field of bone nonunion and epidemiological and etiological data. We aim to communicate economical and effective treatment methods, improve patients’ prognosis, and reduce the social medical burden, with an eye toward the future.
We welcome submissions of Original Research, Review, on the subtopics of, but not limited to:
• Update of epidemiological data and establishment of clinical prediction models of bone nonunion
• Study on pathogenesis, clinical screening and markers for nonunion
• Application of new techniques in bone nonunion surgery
• Recent advances in nonsurgical therapy of nonunion including Low-intensity pulsed ultrasound (LIPUS), Electrical stimulation, Hyperbaric oxygen (HBO) and Extracorporeal shock wave stimulation (ESWT).
• Advances in tissue stimulation and engineering treatments of nonunion, such as percutaneous autologous concentrated bone marrow injection, stem cell therapy, cytokine therapy and scaffold loading materials.
Bone nonunion (BN) is a refractory condition in which the body is unable to heal a fracture without medical or surgical intervention. Even after mitigating various sources of risk including inappropriate surgery, infection, malnutrition and metabolic abnormalities, a considerable number of fracture patients still suffer from BN. There are a range of different X-ray manifestations of BN, which can include atrophic, oligotrophic and hypertrophic nonunions and in chronic cases, pseudarthrosis. Once BN occurs, patients may experience disabling morbidity. This may be due to the affected limb being unable to bear weight for an extended period of time which can then threaten not only associated joints but also systemic functions. In addition, effective clinical treatments for BN are still limited with a lack of in-depth research on new therapeutic technologies.
Rapid economic and industrial developments around the world have led to increased traffic accidents and other traumatic mechanisms in recent years. Thus, the incidence of BN is also rising, leading to an increased economic burden on patients, their families, and social medical costs. Therefore, developing a efficient and effective treatment for fracture nonunion is crucial.
This Research Topic aims to shed light on the latest clinical cases and treatments for bone nonunion. We also wish to explore the basic research progress in the field of bone nonunion and epidemiological and etiological data. We aim to communicate economical and effective treatment methods, improve patients’ prognosis, and reduce the social medical burden, with an eye toward the future.
We welcome submissions of Original Research, Review, on the subtopics of, but not limited to:
• Update of epidemiological data and establishment of clinical prediction models of bone nonunion
• Study on pathogenesis, clinical screening and markers for nonunion
• Application of new techniques in bone nonunion surgery
• Recent advances in nonsurgical therapy of nonunion including Low-intensity pulsed ultrasound (LIPUS), Electrical stimulation, Hyperbaric oxygen (HBO) and Extracorporeal shock wave stimulation (ESWT).
• Advances in tissue stimulation and engineering treatments of nonunion, such as percutaneous autologous concentrated bone marrow injection, stem cell therapy, cytokine therapy and scaffold loading materials.
