Meningitis and pneumonia infection is a serious problem worldwide and the fatality rate remains high in children, especially in neonates, the burden of which is felt largely in developing countries. The severity of the disease varies from asymptomatic chronic infection in adults to systematic complex interaction of host immune response, genetic predisposition and extrinsic modulators of clearance and progression in children below 5 years of age. The main causative agents of disease are Streptococcus pneumonia and Haemophilus influenzae. Being very fragile and fastidious microorganisms, laboratory diagnosis requires fast sample processing. Due to a lack of laboratory facilities and expert laboratory personnel, in most cases treatment remains based on empirical therapeutics. The lack of effective regimens for therapeutics for patients who suffered serious side effects during and after infection have prompted basic science research and numerous clinical trials leading to the development of response predictors. It is crucial to more accurately predict the response to treatment, this can allow for customization of therapy and may help to reduce the significant adverse events and high cost associated with long term hospital stay.
In this Research Topic we aim to attract research scientists and clinicians to share their experience as review articles and original research, among other article types accepted by Frontiers, to explore the new predictors of meningitis and pneumonia as caused by Streptococcus pneumonia and Haemophilus influenzae, with a view of helping to guide clinical diagnosis and treatment decisions.
This Research Topic welcomes the following potential sub-themes:
- Development of diagnostic tools and molecular characterization of meningitis and pneumonia disease-causing agents
- Immunopathogenesis and immunologic predictors of treatment response to meningitis and pneumonia
- Response predictors of diagnosis and prognosis in Streptococcus pneumonia and Haemophilus influenzae
- Predictors of response to meningitis and pneumonia therapy
- Genetic predictors of meningitis, and pneumonia
- Epigenetics and microRNA as predictors for meningitis and pneumonia
- The role of microRNA and its targets in meningitis and pneumonia pathogenesis and treatment
- Interaction and co-infections with other pathogens during meningitis and pneumonia
- Pathogenicity and virulence determinants of Streptococcus pneumonia and Haemophilus influenzae causing meningitis and pneumonia
Meningitis and pneumonia infection is a serious problem worldwide and the fatality rate remains high in children, especially in neonates, the burden of which is felt largely in developing countries. The severity of the disease varies from asymptomatic chronic infection in adults to systematic complex interaction of host immune response, genetic predisposition and extrinsic modulators of clearance and progression in children below 5 years of age. The main causative agents of disease are Streptococcus pneumonia and Haemophilus influenzae. Being very fragile and fastidious microorganisms, laboratory diagnosis requires fast sample processing. Due to a lack of laboratory facilities and expert laboratory personnel, in most cases treatment remains based on empirical therapeutics. The lack of effective regimens for therapeutics for patients who suffered serious side effects during and after infection have prompted basic science research and numerous clinical trials leading to the development of response predictors. It is crucial to more accurately predict the response to treatment, this can allow for customization of therapy and may help to reduce the significant adverse events and high cost associated with long term hospital stay.
In this Research Topic we aim to attract research scientists and clinicians to share their experience as review articles and original research, among other article types accepted by Frontiers, to explore the new predictors of meningitis and pneumonia as caused by Streptococcus pneumonia and Haemophilus influenzae, with a view of helping to guide clinical diagnosis and treatment decisions.
This Research Topic welcomes the following potential sub-themes:
- Development of diagnostic tools and molecular characterization of meningitis and pneumonia disease-causing agents
- Immunopathogenesis and immunologic predictors of treatment response to meningitis and pneumonia
- Response predictors of diagnosis and prognosis in Streptococcus pneumonia and Haemophilus influenzae
- Predictors of response to meningitis and pneumonia therapy
- Genetic predictors of meningitis, and pneumonia
- Epigenetics and microRNA as predictors for meningitis and pneumonia
- The role of microRNA and its targets in meningitis and pneumonia pathogenesis and treatment
- Interaction and co-infections with other pathogens during meningitis and pneumonia
- Pathogenicity and virulence determinants of Streptococcus pneumonia and Haemophilus influenzae causing meningitis and pneumonia