General anesthetics (GA), including ketamine, nitrous oxide, propofol, isoflurane and sevoflurane, have been widely applied to clinic surgery. Aging and developing brains are particularly vulnerable to anesthetics, which may lead to neuronal damage. Growing evidence of human cohort studies demonstrates that these patients of vulnerable brains had a higher incidence of perioperative neurocognitive disorders (PND) and long-term cognitive decline.
The aim of the current Research Topic is to cover novel, rigorous and promising research in the field of anesthetic-induced neurotoxicity and neurocognitive impairment, to address the different effects of anesthetics on aging and developing neurons, and the underlying mechanisms. Moreover, we aim to gather pre-clinical and clinical research providing a joint commentary on strategy to guide clinical anesthesia and neurocognitive protection.
We welcome submissions focused on anesthetic-induced neurotoxicity and neurocognitive impairment of aging and developing brains, including pre-clinical and clinical studies. Methods for addressing these questions may include but not limited to animal models, routine laboratory techniques, neuroimaging, psychophysiology, genetics, real world research, longitudinal and multi-center designs. We welcome submissions of the following article types: Brief Research Report, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Review, Study Protocol, and Systematic Review. Areas to be covered in this Research Topic may include, but are not limited to:
• Causal-effects of anesthetics and neurotoxicity under routine clinical anesthesia dose
• Molecular mechanism of anesthetic-induced neurotoxicity
• Causal-effects of anesthetics and perioperative neurocognitive disorders
• Molecular, circuit, network mechanism of neurocognitive impairment
• Biomarkers, correlates, and predictors of neurocognitive impairment
• Potential effects of adjuvant drugs administered during anesthesia on cognitive function
• Clinical implication for practice in anesthesia and cognitive protection
General anesthetics (GA), including ketamine, nitrous oxide, propofol, isoflurane and sevoflurane, have been widely applied to clinic surgery. Aging and developing brains are particularly vulnerable to anesthetics, which may lead to neuronal damage. Growing evidence of human cohort studies demonstrates that these patients of vulnerable brains had a higher incidence of perioperative neurocognitive disorders (PND) and long-term cognitive decline.
The aim of the current Research Topic is to cover novel, rigorous and promising research in the field of anesthetic-induced neurotoxicity and neurocognitive impairment, to address the different effects of anesthetics on aging and developing neurons, and the underlying mechanisms. Moreover, we aim to gather pre-clinical and clinical research providing a joint commentary on strategy to guide clinical anesthesia and neurocognitive protection.
We welcome submissions focused on anesthetic-induced neurotoxicity and neurocognitive impairment of aging and developing brains, including pre-clinical and clinical studies. Methods for addressing these questions may include but not limited to animal models, routine laboratory techniques, neuroimaging, psychophysiology, genetics, real world research, longitudinal and multi-center designs. We welcome submissions of the following article types: Brief Research Report, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Review, Study Protocol, and Systematic Review. Areas to be covered in this Research Topic may include, but are not limited to:
• Causal-effects of anesthetics and neurotoxicity under routine clinical anesthesia dose
• Molecular mechanism of anesthetic-induced neurotoxicity
• Causal-effects of anesthetics and perioperative neurocognitive disorders
• Molecular, circuit, network mechanism of neurocognitive impairment
• Biomarkers, correlates, and predictors of neurocognitive impairment
• Potential effects of adjuvant drugs administered during anesthesia on cognitive function
• Clinical implication for practice in anesthesia and cognitive protection