Cellular senescence is a natural state of irreversible cell-cycle arrest triggered by various intracellular or extracellular stress stimuli and it is conserved across mammalian species.
Despite being in a permanent arrested state, senescent cells are metabolically active and they produce a variety of secretory factors, in what is known as senescence-associated secretory phenotype (SASP), that can ultimately affect the neighboring cells.
Cell senescence is generally considered to act as tumor-suppressive mechanism and overcoming it is one key step for cancer development and progression. Among the major regulators of cell senescence there are several tumor suppressor genes, like p53, p21, p27, and Rb, but the mechanisms how tumor cells can overcome cell senescence are still elusive.
This Research Topic aims to elucidate the molecular mechanisms associated to cell senescence and tumor escape from senescence, with the final goal to provide novel perspectives for therapeutic application for cancer treatment.
We welcome Original Research Articles, Reviews, and Systematic Reviews focus on but are not limited to:
- Molecular factor involved in the regulation of cell senescence
- Signaling pathway involved in cell senescence
- Role of the senescence-associated secretory phenotype
- Developing of therapy-induced senescence strategies
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Cellular senescence is a natural state of irreversible cell-cycle arrest triggered by various intracellular or extracellular stress stimuli and it is conserved across mammalian species.
Despite being in a permanent arrested state, senescent cells are metabolically active and they produce a variety of secretory factors, in what is known as senescence-associated secretory phenotype (SASP), that can ultimately affect the neighboring cells.
Cell senescence is generally considered to act as tumor-suppressive mechanism and overcoming it is one key step for cancer development and progression. Among the major regulators of cell senescence there are several tumor suppressor genes, like p53, p21, p27, and Rb, but the mechanisms how tumor cells can overcome cell senescence are still elusive.
This Research Topic aims to elucidate the molecular mechanisms associated to cell senescence and tumor escape from senescence, with the final goal to provide novel perspectives for therapeutic application for cancer treatment.
We welcome Original Research Articles, Reviews, and Systematic Reviews focus on but are not limited to:
- Molecular factor involved in the regulation of cell senescence
- Signaling pathway involved in cell senescence
- Role of the senescence-associated secretory phenotype
- Developing of therapy-induced senescence strategies
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.