Recent advances made in sequencing technologies and bioinformatics analysis have revealed a large amount of fungal secondary metabolism (SM) encoding genes, which are called biosynthetic gene clusters (BGCs). However, only a few BGCs have been functionally annotated and correctly assigned to the relative metabolites to date. One of the major reasons hindering the identification of BGCs is the poor understanding of how these BGCs are regulated. On the other hand, genetic manipulations of regulators are efficient to activate these BGCs, which have made significant progress, ranging from overexpression of pathway-specific regulators to deletion of epigenetic blocks of BGC expression to gain access to new fungal SMs. In this research topic, we will focus on the recent achievements made in elucidating regulator mechanisms of fungal SMs and in mining novel SMs in fungi via genetic manipulations of various types of regulators, etc.
This research topic seeks contributions in this area related to regulatory elements and network of fungal secondary metabolisms, activation of biosynthetic gene clusters of fungal secondary metabolites via genetic approach, and the deep molecular mechanism of regulators linking between fungal secondary metabolites and biological activities.
We more specifically welcome manuscripts to the following fields, but are not limited to:
· Genetic and biochemical approaches to define regulatory aspects of fungal secondary metabolism
· Systems biology approaches to define regulatory networks that affect fungal secondary metabolism
· Genetic manipulations of regulators to activate biosynthetic gene clusters of fungal secondary metabolites
· Genetic approaches to engineer fungal secondary metabolism
· Transcriptional, translational, and epigenetic control of fungal secondary metabolism
· The transcriptional and epigenetic activation of biosynthetic gene clusters of fungal secondary metabolites
Recent advances made in sequencing technologies and bioinformatics analysis have revealed a large amount of fungal secondary metabolism (SM) encoding genes, which are called biosynthetic gene clusters (BGCs). However, only a few BGCs have been functionally annotated and correctly assigned to the relative metabolites to date. One of the major reasons hindering the identification of BGCs is the poor understanding of how these BGCs are regulated. On the other hand, genetic manipulations of regulators are efficient to activate these BGCs, which have made significant progress, ranging from overexpression of pathway-specific regulators to deletion of epigenetic blocks of BGC expression to gain access to new fungal SMs. In this research topic, we will focus on the recent achievements made in elucidating regulator mechanisms of fungal SMs and in mining novel SMs in fungi via genetic manipulations of various types of regulators, etc.
This research topic seeks contributions in this area related to regulatory elements and network of fungal secondary metabolisms, activation of biosynthetic gene clusters of fungal secondary metabolites via genetic approach, and the deep molecular mechanism of regulators linking between fungal secondary metabolites and biological activities.
We more specifically welcome manuscripts to the following fields, but are not limited to:
· Genetic and biochemical approaches to define regulatory aspects of fungal secondary metabolism
· Systems biology approaches to define regulatory networks that affect fungal secondary metabolism
· Genetic manipulations of regulators to activate biosynthetic gene clusters of fungal secondary metabolites
· Genetic approaches to engineer fungal secondary metabolism
· Transcriptional, translational, and epigenetic control of fungal secondary metabolism
· The transcriptional and epigenetic activation of biosynthetic gene clusters of fungal secondary metabolites
