Interferons are proteins involved in inducing vertebrate cells into an antiviral state. There are four families of IFNs in vertebrates, type I IFN, type II IFN, IFN-?, and IFN-?, that are distinguished by genetic code, protein structure, and functionality. IFN-?, type I and type II IFN families have been found to be important in the antiviral defenses of teleost fish. The fish type I IFN family is divided into two subfamilies, with distinct signaling receptors. The fish type II IFN is also divided into two subfamilies, IFN-? with similar functions to mammalian IFN-? and a teleost specific IFN-? related (IFN-?rel) molecule whose functions are not fully elucidated. Each type II IFN subfamily has unique receptors to bind to in order to exert their function. IFN-? and its receptors, including IFN-?R1 (ifnur1, also known as crfb12 in fish) and CRFB4/IL-10R2, have been recently identified in different vertebrates. Fish IFN signaling is regulated by host pattern recognition receptors, transcription factors such as IFN regulatory factors, the Jak/Stat proteins and the suppressor of cytokine signaling (SOCS) molecules.
In this Research Topic, we aim to provide an update on interferon signaling in teleost fish. Welcome submissions interferon receptors and molecular mechanisms of interferon signaling in teleost fish. We also welcome comparative analyses of interferon signaling in different species of teleost fish. We also welcome manuscripts covering the therapeutic application of interferon signaling in teleost. We welcome the submission of Original Research, Review, Mini Review, Perspective, and Opinion articles covering, but not limited to, the following subtopics:
• Novel mechanisms of interferon signaling in teleost
• Regulation of interferon signaling in teleost
• Reviews of our current understanding of interferon signaling in teleost
• Evolution of interferon signaling and receptor evolution in teleost
• Comparative structure/function relationship of receptors
• Comparison of interferon signaling and receptors in different species of teleost fish
• Therapeutics targeting interferon signaling in teleost
Interferons are proteins involved in inducing vertebrate cells into an antiviral state. There are four families of IFNs in vertebrates, type I IFN, type II IFN, IFN-?, and IFN-?, that are distinguished by genetic code, protein structure, and functionality. IFN-?, type I and type II IFN families have been found to be important in the antiviral defenses of teleost fish. The fish type I IFN family is divided into two subfamilies, with distinct signaling receptors. The fish type II IFN is also divided into two subfamilies, IFN-? with similar functions to mammalian IFN-? and a teleost specific IFN-? related (IFN-?rel) molecule whose functions are not fully elucidated. Each type II IFN subfamily has unique receptors to bind to in order to exert their function. IFN-? and its receptors, including IFN-?R1 (ifnur1, also known as crfb12 in fish) and CRFB4/IL-10R2, have been recently identified in different vertebrates. Fish IFN signaling is regulated by host pattern recognition receptors, transcription factors such as IFN regulatory factors, the Jak/Stat proteins and the suppressor of cytokine signaling (SOCS) molecules.
In this Research Topic, we aim to provide an update on interferon signaling in teleost fish. Welcome submissions interferon receptors and molecular mechanisms of interferon signaling in teleost fish. We also welcome comparative analyses of interferon signaling in different species of teleost fish. We also welcome manuscripts covering the therapeutic application of interferon signaling in teleost. We welcome the submission of Original Research, Review, Mini Review, Perspective, and Opinion articles covering, but not limited to, the following subtopics:
• Novel mechanisms of interferon signaling in teleost
• Regulation of interferon signaling in teleost
• Reviews of our current understanding of interferon signaling in teleost
• Evolution of interferon signaling and receptor evolution in teleost
• Comparative structure/function relationship of receptors
• Comparison of interferon signaling and receptors in different species of teleost fish
• Therapeutics targeting interferon signaling in teleost