Obesity rates continue to increase around the world, despite efforts to improve weight outcomes using both individual and population-based approaches. While the principle of energy homeostasis has been the primary framework for addressing obesity, the diverse biobehavioural considerations connected to energy intake and expenditure require further attention. These include omics, neural, and environmental considerations, and their potential interrelationships or interactions, which contribute to food intake and physical activity. Further investigation of these biobehavioral factors will improve the understanding of obesity and lead to novel intervention strategies.
The aim of this Research Topic is to highlight these complex contributors to obesity, encompassing both eating behavior and physical activity. We welcome Original Research and Review articles covering the below topics. Primary studies can be conducted using animal models or human studies (observational, experimental, or interventional). Integrative studies involving multi-omics and systems biology are of particular interest.
1. Genetic association studies and gene-environment interaction studies examining genetic contributors to food intake, appetite, or physical activity.
2. Mediation or moderation analyses examining relationships between genetic variation, individual factors (e.g., early life adversity, impulsivity, personality), and eating behaviour or physical activity.
3. Integrative neuroimaging studies involving omics to elucidate neural and cognitive responses to food cues or physical activity-related stimuli, or responses to lifestyle interventions.
4. Consideration of the microbiome in appetite, food intake, and adiposity-related outcomes.
5. Multi-omics or systems biology studies to examine the effects of epigenetic changes on nutrition, metabolism, energy utilization, activity, and feeding behaviors.
Obesity rates continue to increase around the world, despite efforts to improve weight outcomes using both individual and population-based approaches. While the principle of energy homeostasis has been the primary framework for addressing obesity, the diverse biobehavioural considerations connected to energy intake and expenditure require further attention. These include omics, neural, and environmental considerations, and their potential interrelationships or interactions, which contribute to food intake and physical activity. Further investigation of these biobehavioral factors will improve the understanding of obesity and lead to novel intervention strategies.
The aim of this Research Topic is to highlight these complex contributors to obesity, encompassing both eating behavior and physical activity. We welcome Original Research and Review articles covering the below topics. Primary studies can be conducted using animal models or human studies (observational, experimental, or interventional). Integrative studies involving multi-omics and systems biology are of particular interest.
1. Genetic association studies and gene-environment interaction studies examining genetic contributors to food intake, appetite, or physical activity.
2. Mediation or moderation analyses examining relationships between genetic variation, individual factors (e.g., early life adversity, impulsivity, personality), and eating behaviour or physical activity.
3. Integrative neuroimaging studies involving omics to elucidate neural and cognitive responses to food cues or physical activity-related stimuli, or responses to lifestyle interventions.
4. Consideration of the microbiome in appetite, food intake, and adiposity-related outcomes.
5. Multi-omics or systems biology studies to examine the effects of epigenetic changes on nutrition, metabolism, energy utilization, activity, and feeding behaviors.
