Translating tolerogenic therapies to the clinic – where do we stand and what are the barriers?

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Stephen Paul Cobbold

University of Oxford

Houston Methodist Hospital

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This Research Topic is a call for papers to provide an up to date assessment of current attempts to introduce tolerogenic therapies into clinical practice. Tolerance has been a highly sought after goal in the field of organ transplantation for over half a century, and is now readily achievable in rodent models, but considerable barriers remain to successfully translating tolerogenic treatments to the clinic.

The initial call for this Research Topic has been aimed to provide an overview of recent advances made within the European RISET and American ITN networks with regard to tolerogenic strategies in clinical transplantation, autoimmune disease, and allergy. Articles will also cover the barriers to clinical tolerance induction and new emerging approaches to overcome such barriers.

1. Collaborative networks working towards the goal of therapeutic tolerance induction

2. Prope tolerance and minimization of immunosuppression

3. Lessons from operationally tolerant patients

4. Targeted withdrawal of immunosuppression

5. Stem cells and hematopoietic chimerism as a route to tolerance

6. Promoting regulatory T cells

7. Tolerogenic dendritic cells and negative vaccination

8. Inhibitory pathways and mechanisms in tolerance

9. Memory T cells and heterologous immunity

10. The innate response to allotransplants

11. Chronic graft loss--what are the missing links?

12. The impact of graft microenvironment on tolerance

This Research Topic is a call for papers to provide an up to date assessment of current attempts to introduce tolerogenic therapies into clinical practice. Tolerance has been a highly sought after goal in the field of organ transplantation for over half a century, and is now readily achievable in rodent models, but considerable barriers remain to successfully translating tolerogenic treatments to the clinic.

The initial call for this Research Topic has been aimed to provide an overview of recent advances made within the European RISET and American ITN networks with regard to tolerogenic strategies in clinical transplantation, autoimmune disease, and allergy. Articles will also cover the barriers to clinical tolerance induction and new emerging approaches to overcome such barriers.

1. Collaborative networks working towards the goal of therapeutic tolerance induction

2. Prope tolerance and minimization of immunosuppression

3. Lessons from operationally tolerant patients

4. Targeted withdrawal of immunosuppression

5. Stem cells and hematopoietic chimerism as a route to tolerance

6. Promoting regulatory T cells

7. Tolerogenic dendritic cells and negative vaccination

8. Inhibitory pathways and mechanisms in tolerance

9. Memory T cells and heterologous immunity

10. The innate response to allotransplants

11. Chronic graft loss--what are the missing links?

12. The impact of graft microenvironment on tolerance

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Stephen Paul Cobbold

University of Oxford

Houston Methodist Hospital

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Frontiers in Immunology

Immunological Tolerance and Regulation

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