The rickettsiae (formerly including genera rickettsia, orientia, ehrlichia, anaplasma, bartonella and coxiella) are a diverse collection of intracellular Gram-negative bacteria found in ticks, lice, fleas, mites, chiggers, and mammals. Many members of rickettsiae are important causes of human diseases that transmitted by vectors and by aerosol. To promote intracellular replication, these pathogens have developed numerous strategies to subvert host cellular processes and evade immune surveillance. In the last decade, technical advances in high-throughput sequencing and genetic manipulation have greatly facilitated the researches on these bacteria.
With this Research Topic, we intend to describe the most recent advances made in understanding the transmission and pathogenicity of rickettsiae. Indeed, much more in this field is still to be uncovered, such as the vector tropism, the virulence determinants, and the key factors involved in host-microbe interactions. A comprehensive understanding on this topic will not only give us keen insight into bacterial pathogenesis, but also provide new ideas for control and prevention of rickettsial diseases.
This Research Topic is dedicated to studies addressing the transmission and pathogenicity of rickettsiae (including rickettsia, orientia, ehrlichia, anaplasma, bartonella and coxiella). We welcome Original Research articles, Mini-Reviews, and Reviews under the following themes:
- mechanisms of vector transmission, and determination of natural reservoirs;
- elucidation of ligands and receptors, and invasion mechanisms of rickettsiae;
- effector proteins of rickettsiae and their virulence mechanisms;
- experimental models of infection with different vectors, cell lines, or animals;
- analysis of host responses to rickettsial infection using OMICS approaches.
The rickettsiae (formerly including genera rickettsia, orientia, ehrlichia, anaplasma, bartonella and coxiella) are a diverse collection of intracellular Gram-negative bacteria found in ticks, lice, fleas, mites, chiggers, and mammals. Many members of rickettsiae are important causes of human diseases that transmitted by vectors and by aerosol. To promote intracellular replication, these pathogens have developed numerous strategies to subvert host cellular processes and evade immune surveillance. In the last decade, technical advances in high-throughput sequencing and genetic manipulation have greatly facilitated the researches on these bacteria.
With this Research Topic, we intend to describe the most recent advances made in understanding the transmission and pathogenicity of rickettsiae. Indeed, much more in this field is still to be uncovered, such as the vector tropism, the virulence determinants, and the key factors involved in host-microbe interactions. A comprehensive understanding on this topic will not only give us keen insight into bacterial pathogenesis, but also provide new ideas for control and prevention of rickettsial diseases.
This Research Topic is dedicated to studies addressing the transmission and pathogenicity of rickettsiae (including rickettsia, orientia, ehrlichia, anaplasma, bartonella and coxiella). We welcome Original Research articles, Mini-Reviews, and Reviews under the following themes:
- mechanisms of vector transmission, and determination of natural reservoirs;
- elucidation of ligands and receptors, and invasion mechanisms of rickettsiae;
- effector proteins of rickettsiae and their virulence mechanisms;
- experimental models of infection with different vectors, cell lines, or animals;
- analysis of host responses to rickettsial infection using OMICS approaches.