Increasing evidence indicates that inflammation is a powerful homeostatic mechanism, aimed at maintaining/restoring tissue integrity. Sterile inflammation is a common event, triggered by physical, chemical or metabolic noxiae. The different noxiae cause cell stress and hence stress responses. Many types of stress response exist (e.g. unfolding protein response, integrated stress response, oxidative stress), often entangled among each others. Stress responses trigger inflammation. When noxiae persist, inflammation does not resolve, resulting in a vicious circle that has a key role in the pathophysiology of many human disorders, including cancer, metabolic and genetic diseases. Several factors have been proposed to play a role in the different types of sterile inflammation, including redox remodeling, DAMPs, heat shock proteins. However, the mechanism(s) linking stressful events and inflammation is so far elusive. The identification of the major molecular player(s) in induction, development and outcome of sterile inflammation, and the definition of the way they work, are therefore of paramount relevance for the design of effective therapeutic strategies for the treatment of the most common diseases of the Western world. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for onset, development and outcome of sterile inflammation.
Increasing evidence indicates that inflammation is a powerful homeostatic mechanism, aimed at maintaining/restoring tissue integrity. Sterile inflammation is a common event, triggered by physical, chemical or metabolic noxiae. The different noxiae cause cell stress and hence stress responses. Many types of stress response exist (e.g. unfolding protein response, integrated stress response, oxidative stress), often entangled among each others. Stress responses trigger inflammation. When noxiae persist, inflammation does not resolve, resulting in a vicious circle that has a key role in the pathophysiology of many human disorders, including cancer, metabolic and genetic diseases. Several factors have been proposed to play a role in the different types of sterile inflammation, including redox remodeling, DAMPs, heat shock proteins. However, the mechanism(s) linking stressful events and inflammation is so far elusive. The identification of the major molecular player(s) in induction, development and outcome of sterile inflammation, and the definition of the way they work, are therefore of paramount relevance for the design of effective therapeutic strategies for the treatment of the most common diseases of the Western world. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for onset, development and outcome of sterile inflammation.
