Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, with a significant social, health and economic impact. The current diagnostic criteria for the disease are based on the use of imaging tools and/or the study of biochemical biomarkers. However, early diagnosis of AD is challenging due to the lack of biomarkers for the initial stages of this disease. In this context, it is important to direct attention to mild cognitive impairment, which often represents a prodromal phase of dementia, including AD. In recent years, interest in the search for dementia-related biomarkers in biological fluids and especially in plasma and cerebrospinal fluid (CSF) has increased exponentially. Indeed, more than 300 scientific papers on protein markers of AD in CSF have been published in the last two years. This Research Topic aims to address the latest advances on this field, focusing on body fluid biomarkers in early AD.
We invite authors to submit Original Research articles, Brief Research Reports, Clinical Trial Studies and Review Articles to provide new information on this topic, with emphasis on early detection.
The different areas to be addressed by this Research Topic are as follows:
• Search for novel biomarkers in biological fluids in AD.
• Search for early biomarkers using omics techniques.
• Current role of biomarkers in early diagnosis and progression of AD.
• Use of biomarkers for the classification and categorization of different types of dementia.
• Early biomarkers in other dementias: vascular dementia, frontotemporal dementia, and dementia with Lewy bodies.
• Relevance and interrelationship of potential biomarkers in different body fluids.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, with a significant social, health and economic impact. The current diagnostic criteria for the disease are based on the use of imaging tools and/or the study of biochemical biomarkers. However, early diagnosis of AD is challenging due to the lack of biomarkers for the initial stages of this disease. In this context, it is important to direct attention to mild cognitive impairment, which often represents a prodromal phase of dementia, including AD. In recent years, interest in the search for dementia-related biomarkers in biological fluids and especially in plasma and cerebrospinal fluid (CSF) has increased exponentially. Indeed, more than 300 scientific papers on protein markers of AD in CSF have been published in the last two years. This Research Topic aims to address the latest advances on this field, focusing on body fluid biomarkers in early AD.
We invite authors to submit Original Research articles, Brief Research Reports, Clinical Trial Studies and Review Articles to provide new information on this topic, with emphasis on early detection.
The different areas to be addressed by this Research Topic are as follows:
• Search for novel biomarkers in biological fluids in AD.
• Search for early biomarkers using omics techniques.
• Current role of biomarkers in early diagnosis and progression of AD.
• Use of biomarkers for the classification and categorization of different types of dementia.
• Early biomarkers in other dementias: vascular dementia, frontotemporal dementia, and dementia with Lewy bodies.
• Relevance and interrelationship of potential biomarkers in different body fluids.