The purpose of preclinical studies is to estimate drug candidates' efficacy and toxicity in clinical trials. Therefore, the biomimeticity of the evaluation methods in preclinical studies is crucial. Artificial organs can be used as a highly bionic evaluation method. Multiple technologies can be used to construct artificial organs, such as organ-on-a-chip, organoid, and 3D-bioprinting. Organ-on-a-chip technology takes advantage of flexible fluidic manipulation and fine recreation of the cell microenvironment. Organoid technologies enable personalized mini-organs and allow the development of drugs toward different human species. 3D-bioprinting technologies are capable of establishing artificial organs with extricating 3D structures. They have become an important part of this endeavor to find killer applications in drug development.
To find the killer application, an artificial organ model requires the recreation of the functions of real organs, high throughput, low cost, and ease of experimental operation. Among them, the functions of the artificial organs are crucial, which are related to the microenvironments of cells, including biomaterials, paracrine, fluid shear force, exosomes, etc. This Research Topic aims to collect research advances in how to make artificial organs with enhanced functions by advanced materials.
Topic Editors welcomes the high-quality Original Research and Review articles on organ mimicking, especially appreciating the science or technological breakthrough in the following area on the biomaterial innovation basis:
1. Nerve system regeneration
2. Enzymatic function enhancement in the artificial liver
3. Vascularization in the organ-on-a-chip, organoid, or 3D bioprinting
4. Escalation of the interaction of artificial organ and immune cells
5. Merging of organ-on-a-chip, organoid, and 3D bioprinting technologies
The purpose of preclinical studies is to estimate drug candidates' efficacy and toxicity in clinical trials. Therefore, the biomimeticity of the evaluation methods in preclinical studies is crucial. Artificial organs can be used as a highly bionic evaluation method. Multiple technologies can be used to construct artificial organs, such as organ-on-a-chip, organoid, and 3D-bioprinting. Organ-on-a-chip technology takes advantage of flexible fluidic manipulation and fine recreation of the cell microenvironment. Organoid technologies enable personalized mini-organs and allow the development of drugs toward different human species. 3D-bioprinting technologies are capable of establishing artificial organs with extricating 3D structures. They have become an important part of this endeavor to find killer applications in drug development.
To find the killer application, an artificial organ model requires the recreation of the functions of real organs, high throughput, low cost, and ease of experimental operation. Among them, the functions of the artificial organs are crucial, which are related to the microenvironments of cells, including biomaterials, paracrine, fluid shear force, exosomes, etc. This Research Topic aims to collect research advances in how to make artificial organs with enhanced functions by advanced materials.
Topic Editors welcomes the high-quality Original Research and Review articles on organ mimicking, especially appreciating the science or technological breakthrough in the following area on the biomaterial innovation basis:
1. Nerve system regeneration
2. Enzymatic function enhancement in the artificial liver
3. Vascularization in the organ-on-a-chip, organoid, or 3D bioprinting
4. Escalation of the interaction of artificial organ and immune cells
5. Merging of organ-on-a-chip, organoid, and 3D bioprinting technologies
