Parasitic diseases are still the primary diseases that seriously threaten human health and life, and liver disease is the leading cause of morbidity and mortality for various parasitic diseases, such as schistosomiasis, clonorchiasis, and hydatidosis. Most of parasite-induced liver diseases, including liver injury, inflammation, fibrosis, cirrhosis, and even liver cancer, are still lack of effective therapies. The interactions between parasites and host hepatic resident cells or recruited inflammatory cells are fundamental to the occurrence of these pathologies. A better understanding of the mechanisms underpinning these pathologies is the key to developing novel therapeutic interventions for these debilitating diseases.
This Research Topic aims to provide a unique perspective for understanding the cellular and molecular mechanisms of liver pathologies induced by parasite infections and developing new biomarker-based diagnostics and treatment modalities for these debilitating hepatic diseases.
We welcome high-quality contributions, including Original Research and Review, addressing the following topics:
• Key parasite-derived pathogenetic molecules responsible for the development of liver diseases
• Key host cellular and molecular mechanisms regulating the initiation, progression and regression of parasite-induced liver diseases
• Novel biomarkers for diagnosis and prognosis of parasite-induced liver diseases
• Novel therapeutic interventions for parasite-induced liver diseases
• Omics research in parasitic liver diseases
• Animal models for studying parasitic liver diseases
Parasitic diseases are still the primary diseases that seriously threaten human health and life, and liver disease is the leading cause of morbidity and mortality for various parasitic diseases, such as schistosomiasis, clonorchiasis, and hydatidosis. Most of parasite-induced liver diseases, including liver injury, inflammation, fibrosis, cirrhosis, and even liver cancer, are still lack of effective therapies. The interactions between parasites and host hepatic resident cells or recruited inflammatory cells are fundamental to the occurrence of these pathologies. A better understanding of the mechanisms underpinning these pathologies is the key to developing novel therapeutic interventions for these debilitating diseases.
This Research Topic aims to provide a unique perspective for understanding the cellular and molecular mechanisms of liver pathologies induced by parasite infections and developing new biomarker-based diagnostics and treatment modalities for these debilitating hepatic diseases.
We welcome high-quality contributions, including Original Research and Review, addressing the following topics:
• Key parasite-derived pathogenetic molecules responsible for the development of liver diseases
• Key host cellular and molecular mechanisms regulating the initiation, progression and regression of parasite-induced liver diseases
• Novel biomarkers for diagnosis and prognosis of parasite-induced liver diseases
• Novel therapeutic interventions for parasite-induced liver diseases
• Omics research in parasitic liver diseases
• Animal models for studying parasitic liver diseases