Uveal melanoma (UM) is the most common primary intraocular tumor, and includes melanoma of the choroid, ciliary body and iris of the eye. Several genetic and epigenetic alterations and risk factors are involved in the development and metastatic progression of UM. This relatively rare malignancy is associated with poor prognosis, with a strong tendency to metastasize. The current treatment modalities for this cancer include resection, plaque brachytherapy and enucleation.
The aim of this Research Topic is to provide a detailed overview of new advanced therapies in the field of chemotherapy and immunotherapy for UM. Ongoing trials investigating the role of new agents or suggesting new combined therapy in metastatic UM, as well as the identification of new prognosis markers should also be highlighted.
The principle aims of the present Research Topic are focalized on the following themes:
- Identification of new molecular targets and diagnostic biomarkers for UM
- Ongoing clinical trials in metastatic UM
- New perspectives to the therapeutic approach and recent advances in prognostic tools for UM.
This Research Topic welcomes submissions submitted in the form of original and review articles relating to biological, biochemical, molecular, genomic, proteomic, as well as clinical studies focused on uveal melanomas.
Uveal melanoma (UM) is the most common primary intraocular tumor, and includes melanoma of the choroid, ciliary body and iris of the eye. Several genetic and epigenetic alterations and risk factors are involved in the development and metastatic progression of UM. This relatively rare malignancy is associated with poor prognosis, with a strong tendency to metastasize. The current treatment modalities for this cancer include resection, plaque brachytherapy and enucleation.
The aim of this Research Topic is to provide a detailed overview of new advanced therapies in the field of chemotherapy and immunotherapy for UM. Ongoing trials investigating the role of new agents or suggesting new combined therapy in metastatic UM, as well as the identification of new prognosis markers should also be highlighted.
The principle aims of the present Research Topic are focalized on the following themes:
- Identification of new molecular targets and diagnostic biomarkers for UM
- Ongoing clinical trials in metastatic UM
- New perspectives to the therapeutic approach and recent advances in prognostic tools for UM.
This Research Topic welcomes submissions submitted in the form of original and review articles relating to biological, biochemical, molecular, genomic, proteomic, as well as clinical studies focused on uveal melanomas.