Neuropsychiatric Disorders are the leading cause of disability around the world according to reports from the World Health Organization. Treatment strategies, although effective, are still limited by their side effects, slow response, and low efficacy in particular cases. It is estimated that approximately 80% of the global population use herbal medicinal products as a primary source of healthcare, which in most of the cases is devoid of controlled evaluations that limit their therapeutic use. Thus, there is a real need to scientifically evaluate the pharmacological, toxicological and potential therapeutic effects of isolated, characterized and dosed plant secondary metabolites from a multidisciplinary point of view. Advanced technological tools, molecular and cellular methodology, and valid animal models may serve as a platform for the identification of novel plant bioactive metabolites for the treatment of neuropsychiatric disorders.
The goal of this research topic is to provide an overview of the latest preclinical, clinical, and translational research findings in the pharmacological and therapeutics application of plant secondary metabolites on neuropsychiatric disorders (i.e., depression, anxiety, obsessive-compulsive disorder, and neurodegenerative disorders, among others). A specific focus will be placed on discussing the latest and most powerful ways to evaluate the pharmacological actions of plant secondary metabolites using in vitro and in vivo models. Topics to be covered include the pharmacological evaluation of extracts and secondary metabolites of plants in genetic models, pharmacological models, environment/social models, behavioral paradigms, and other experimental approaches. In addition, physician-scientist contributors will also provide translational perspectives on how these results from preclinical research may impact in the treatment of human disorders. This collection of original research and reviews will provide readers with a complete overview of the current state of the pharmacological research of plant secondary metabolites on neuropsychiatric disorders and therapeutics.
The scope of this topic is to bring together relevant international researchers from the pharmacological evaluation of plant secondary metabolites field to build up an international panorama of original research, perspectives and relevant reviews that evaluates those natural products as therapeutic tools in neuropsychiatric disorders. Researchers with a wide range of opinions are welcome to submit their contribution, as long as they provide scientific evidence to support their ideas. We particularly welcome submission of data on the mechanism of action, pharmacological activity, interaction between plant secondary metabolites and clinical effective drugs, evidence of effective therapeutic effects of those natural products in clinical trials, and original results showing potential toxic effects of secondary metabolites with potential use in the treatment of neuropsychiatric disorders. It is an exciting topic and an excellent opportunity for an update on what is new in natural products research, applied to neuropsychiatric disorders and therapeutics.
Neuropsychiatric Disorders are the leading cause of disability around the world according to reports from the World Health Organization. Treatment strategies, although effective, are still limited by their side effects, slow response, and low efficacy in particular cases. It is estimated that approximately 80% of the global population use herbal medicinal products as a primary source of healthcare, which in most of the cases is devoid of controlled evaluations that limit their therapeutic use. Thus, there is a real need to scientifically evaluate the pharmacological, toxicological and potential therapeutic effects of isolated, characterized and dosed plant secondary metabolites from a multidisciplinary point of view. Advanced technological tools, molecular and cellular methodology, and valid animal models may serve as a platform for the identification of novel plant bioactive metabolites for the treatment of neuropsychiatric disorders.
The goal of this research topic is to provide an overview of the latest preclinical, clinical, and translational research findings in the pharmacological and therapeutics application of plant secondary metabolites on neuropsychiatric disorders (i.e., depression, anxiety, obsessive-compulsive disorder, and neurodegenerative disorders, among others). A specific focus will be placed on discussing the latest and most powerful ways to evaluate the pharmacological actions of plant secondary metabolites using in vitro and in vivo models. Topics to be covered include the pharmacological evaluation of extracts and secondary metabolites of plants in genetic models, pharmacological models, environment/social models, behavioral paradigms, and other experimental approaches. In addition, physician-scientist contributors will also provide translational perspectives on how these results from preclinical research may impact in the treatment of human disorders. This collection of original research and reviews will provide readers with a complete overview of the current state of the pharmacological research of plant secondary metabolites on neuropsychiatric disorders and therapeutics.
The scope of this topic is to bring together relevant international researchers from the pharmacological evaluation of plant secondary metabolites field to build up an international panorama of original research, perspectives and relevant reviews that evaluates those natural products as therapeutic tools in neuropsychiatric disorders. Researchers with a wide range of opinions are welcome to submit their contribution, as long as they provide scientific evidence to support their ideas. We particularly welcome submission of data on the mechanism of action, pharmacological activity, interaction between plant secondary metabolites and clinical effective drugs, evidence of effective therapeutic effects of those natural products in clinical trials, and original results showing potential toxic effects of secondary metabolites with potential use in the treatment of neuropsychiatric disorders. It is an exciting topic and an excellent opportunity for an update on what is new in natural products research, applied to neuropsychiatric disorders and therapeutics.
