Colorectal cancer (CRC), as the third most frequently diagnosed malignancy in the world, seriously threatens people’s life. Postoperative chemotherapy can reduce the tumor recurrence rate and prolong patient life, but systemic toxicity and resistance to chemotherapeutic drugs reduce their effectiveness. Therefore, novel strategies for enhancing the chemotherapeutic efficacy of CRC and reducing the side effects are of great importance. To date, many strategies are put into clinical settings in enhancing the chemotherapeutic efficacy of CRC, such as the development of individualized chemotherapy regimens, the modulation of CRC stem cells (including the tumor microenvironment and surface markers) to inhibit chemotherapy resistance of CRC, discovering new targets for CRC chemotherapy. In addition, nanoparticles transporting classical drugs have also been widely used for targeted therapy for CRC and showed fewer side effects. Depending on the physicochemical properties, biomaterials-based nanoparticles can release loaded agents in tumor sites, enhance the therapeutic effects in vivo, and reduce systematic side effects. Therefore, in this Research Topic, we aim to collect and summarize novel strategies in improving the chemotherapeutic efficacy of CRC and provide alternative treatment methods for CRC patients.
We welcome submissions of Original Research and Review articles. Case Reports with important value in improving the chemotherapeutic efficacy of CRC will also be considered. Topics of interest include but are not limited to
• Development of individualized chemotherapy regimens for CRC patients.
• Development of biomaterials-based nanoparticles for chemotherapeutic drug delivery for CRC treatment.
• Regulation of CRC stem cells to inhibit chemotherapy resistance.
• Identification of chemotherapeutic targets for CRC treatment.
Colorectal cancer (CRC), as the third most frequently diagnosed malignancy in the world, seriously threatens people’s life. Postoperative chemotherapy can reduce the tumor recurrence rate and prolong patient life, but systemic toxicity and resistance to chemotherapeutic drugs reduce their effectiveness. Therefore, novel strategies for enhancing the chemotherapeutic efficacy of CRC and reducing the side effects are of great importance. To date, many strategies are put into clinical settings in enhancing the chemotherapeutic efficacy of CRC, such as the development of individualized chemotherapy regimens, the modulation of CRC stem cells (including the tumor microenvironment and surface markers) to inhibit chemotherapy resistance of CRC, discovering new targets for CRC chemotherapy. In addition, nanoparticles transporting classical drugs have also been widely used for targeted therapy for CRC and showed fewer side effects. Depending on the physicochemical properties, biomaterials-based nanoparticles can release loaded agents in tumor sites, enhance the therapeutic effects in vivo, and reduce systematic side effects. Therefore, in this Research Topic, we aim to collect and summarize novel strategies in improving the chemotherapeutic efficacy of CRC and provide alternative treatment methods for CRC patients.
We welcome submissions of Original Research and Review articles. Case Reports with important value in improving the chemotherapeutic efficacy of CRC will also be considered. Topics of interest include but are not limited to
• Development of individualized chemotherapy regimens for CRC patients.
• Development of biomaterials-based nanoparticles for chemotherapeutic drug delivery for CRC treatment.
• Regulation of CRC stem cells to inhibit chemotherapy resistance.
• Identification of chemotherapeutic targets for CRC treatment.
