Over the last three decades, neoplasms have become the largest cause of human mortality due to both high tumor incidence and mortality. In many cancers, mutation or abnormal expression of protein kinases is correlated with tumorigenesis, metastasis, and resistance to chemotherapy. Protein kinases catalyze the phosphorylation of proteins and are involved in multiple cellular processes, and are the key nodes in the cancer signaling network. Therefore, it makes protein kinases great targets for cancer prevention or treatment.
The World Health Organization indicates that one-third of all cancer deaths are preventable. Based on this idea, the use of food or food supplements has increased dramatically in cancer prevention because of perceived health benefits that are presumably acquired without unpleasant side effects. There are currently 71 small-molecule kinase inhibitors (SMKIs) approved by the FDA for cancer treatment. There are approximately 155 kinases currently being explored as targets, representing only about 30% of the human kinome. This indicates that there are still substantial unexplored kinases that may be suitable as targets for either cancer prevention or therapy.
In this research topic, we welcome research articles, reports, reviews, and perspectives focusing on kinases for either cancer prevention or therapy. Areas to be covered may include but are not restricted to:
1. Novel kinases identified as targets for either cancer prevention or therapy
2. Novel compounds that can inhibit the kinases serve as targets for either cancer prevention or therapy
3. Agents that circumvent aberrant kinase-associated drug resistance
4. Novel kinases as marker for diagnosis or prognosis in cancer treatment
Over the last three decades, neoplasms have become the largest cause of human mortality due to both high tumor incidence and mortality. In many cancers, mutation or abnormal expression of protein kinases is correlated with tumorigenesis, metastasis, and resistance to chemotherapy. Protein kinases catalyze the phosphorylation of proteins and are involved in multiple cellular processes, and are the key nodes in the cancer signaling network. Therefore, it makes protein kinases great targets for cancer prevention or treatment.
The World Health Organization indicates that one-third of all cancer deaths are preventable. Based on this idea, the use of food or food supplements has increased dramatically in cancer prevention because of perceived health benefits that are presumably acquired without unpleasant side effects. There are currently 71 small-molecule kinase inhibitors (SMKIs) approved by the FDA for cancer treatment. There are approximately 155 kinases currently being explored as targets, representing only about 30% of the human kinome. This indicates that there are still substantial unexplored kinases that may be suitable as targets for either cancer prevention or therapy.
In this research topic, we welcome research articles, reports, reviews, and perspectives focusing on kinases for either cancer prevention or therapy. Areas to be covered may include but are not restricted to:
1. Novel kinases identified as targets for either cancer prevention or therapy
2. Novel compounds that can inhibit the kinases serve as targets for either cancer prevention or therapy
3. Agents that circumvent aberrant kinase-associated drug resistance
4. Novel kinases as marker for diagnosis or prognosis in cancer treatment