Repair of musculoskeletal tissue due to disease, trauma, congenital malformations, and aging is a substantial clinical focus, with costs exceeding hundreds of billions of dollars annually. Significant efforts have been undertaken to develop biomaterials-based scaffolds to address these clinical needs. Typical tissue engineering systems may consist of scaffolds, cells, and growth factors. These elements can be used separately or combined to elicit the desired biological response. Scaffolds can be formed from materials such as polymers (synthetic or natural), composites, ceramics, and hydrogels. They can serve as a framework for the deposition of the extracellular matrix (ECM) and facilitate the regeneration of natural tissue. Additionally, scaffolds can deliver cells and therapeutic agents (growth factors, proteins, antibiotics) to the injury site to achieve a better clinical outcome.
This Research Topic “Biomaterials for the Repair and Regeneration of Musculoskeletal Tissue” seeks to highlight recent advances in the development of biomaterials in areas such as dental, craniofacial, and orthopedic applications. Special emphasis will be given to research with significant applicability for clinical translation.
The scope will include topics:
• Biomaterial synthesis and processing techniques as well as characterization of the physicochemical and biological properties.
• Peptide-based or peptide-functionalized scaffolds.
• Development of biomimetic materials and their clinical relevance.
• Smart biomaterials that respond to external or internal signals to promote tissue regeneration.
• 3D-printed biomaterials.
• Surface-modification of biomaterials for orthopedic and craniofacial applications.
• Tissue Engineered scaffolds as delivery vehicles for bioactive molecules.
Repair of musculoskeletal tissue due to disease, trauma, congenital malformations, and aging is a substantial clinical focus, with costs exceeding hundreds of billions of dollars annually. Significant efforts have been undertaken to develop biomaterials-based scaffolds to address these clinical needs. Typical tissue engineering systems may consist of scaffolds, cells, and growth factors. These elements can be used separately or combined to elicit the desired biological response. Scaffolds can be formed from materials such as polymers (synthetic or natural), composites, ceramics, and hydrogels. They can serve as a framework for the deposition of the extracellular matrix (ECM) and facilitate the regeneration of natural tissue. Additionally, scaffolds can deliver cells and therapeutic agents (growth factors, proteins, antibiotics) to the injury site to achieve a better clinical outcome.
This Research Topic “Biomaterials for the Repair and Regeneration of Musculoskeletal Tissue” seeks to highlight recent advances in the development of biomaterials in areas such as dental, craniofacial, and orthopedic applications. Special emphasis will be given to research with significant applicability for clinical translation.
The scope will include topics:
• Biomaterial synthesis and processing techniques as well as characterization of the physicochemical and biological properties.
• Peptide-based or peptide-functionalized scaffolds.
• Development of biomimetic materials and their clinical relevance.
• Smart biomaterials that respond to external or internal signals to promote tissue regeneration.
• 3D-printed biomaterials.
• Surface-modification of biomaterials for orthopedic and craniofacial applications.
• Tissue Engineered scaffolds as delivery vehicles for bioactive molecules.