Reviews in Breast Cancer

Editorial

11 May 2023

Editorial: Reviews in breast cancer

Maria Rosaria De Miglio

and

Claudia Mello-Thoms

4,038 views

13 citations

Editors

Claudia Mello-Thoms

The University of Iowa

Maria Rosaria De Miglio

University of Sassari

Impact

Systematic Review

06 January 2023

Diagnostic value of multiple ultrasound diagnostic techniques for axillary lymph node metastases in breast cancer: A systematic analysis and network meta-analysis

Jun Li

, 5 more and

Xin-Wu Cui

3,038 views

7 citations

Review

04 January 2023

Look how far we have come: BREAST cancer detection education on the international stage

Phuong Dung (Yun) Trieu

, 2 more and

Sarah J. Lewis

4,795 views

19 citations

Systematic Review

16 December 2022

Comparing the outcome between multicentric/multifocal breast cancer and unifocal breast cancer: A systematic review and meta-analysis

Yalan Zhang

, 6 more and

Ailin Song

7,211 views

5 citations

Review

09 November 2022

Overview on population screening for carriers with germline BRCA mutation in China

Huijun Lei

, 4 more and

Tianhui Chen

3,458 views

8 citations

A good diet (e.g. foods rich in dietary fiber, soy isoflavones, fucoxanthin and polyphenols) can reduce intestinal flora dysbiosis and thus harmonize the body to reduce the incidence and metastasis of breast cancer. Diet as an important factor in the stable composition of the host probiotic environment, through intestinal flora regulation. probiotic environmental homeostasis can play an adjuvant anti-cancer role in the progression and metastasis of breast cancer (lung, brain, liver, bone).

Review

07 November 2022

Impact of intestinal dysbiosis on breast cancer metastasis and progression

Jin Zhang

, 6 more and

Guoshuang Shen

7,192 views

15 citations

Systematic Review

28 September 2022

Xinyu Chen

, 6 more and

Huan Luo

4,983 views

5 citations

Systematic Review

15 September 2022

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

Yujing He

, 4 more and

Ning He

Background: The effect of tobacco on breast cancer (BC) is controversial. The purpose of this study was to investigate the relationship between tobacco and BC.

Methods: A search was conducted in PubMed, EBSCO, Web of Science and Cochrane Library databases before February 2022. The adjusted odd ratio (OR) and corresponding 95% confidence interval (CI) were used to examine the relationship between active or passive smoking and BC risk.

Results: A total of 77 articles composed of 2,326,987 participants were included for this meta-analysis. Active (OR=1.15, 95% CI=1.11-1.20, p<0.001) and passive (OR=1.17, 95% CI=1.09-1.24, p<0.001) smoking increased the risk of BC in the female population, especially premenopausal BC (active smoking: OR=1.24, p<0.001; passive smoking: OR=1.29, p<0.001), but had no effect on postmenopausal BC (active smoking: OR=1.03, p=0.314; passive smoking: OR=1.13, p=0.218). Active smoking increased the risk of estrogen receptor-positive (ER+) BC risk (OR=1.13, p<0.001), but had no effect on estrogen receptor-negative (ER-) BC (OR=1.08, p=0.155). The risk of BC was positively associated with the duration and intensity of smoking, negatively associated with the duration of smoking cessation. Active smoking increased the risk of BC in the multiparous population (OR=1.13, p<0.001), but had no effect on the nulliparous population (OR=1.05, p=0.432), and smoking before the first birth (OR=1.22, 95% CI=1.17-1.27) had a greater impact on the risk of BC than smoking after the first birth (OR=1.08, 95% CI=1.04-1.12).

Conclusion: Smoking (active and passive) increased the risk of BC in women. The effect of smoking on BC was influenced by smoking-related factors (duration, intensity, years of quitting), population-related factors (fertility status), and BC subtypes.

Systematic Review Registration: identifier CRD42022322699.

9,548 views

17 citations

Within the endosomal system, internalized contents through endocytosis are sorted into early endosomes, which subsequently mature into late endosomes/multivesicular bodies (MVBs). sEVs are released from the fusion of MVBs and the plasma membrane. sEVs accommodate lipids, nucleic acids (DNA, mRNA, and non-coding RNA), and proteins (surface and intra-vesicular molecules). Middle/large EVs bud directly from the plasma membrane. EV, extracellular vesicle.

Review

23 September 2022

The roles of small extracellular vesicles as prognostic biomarkers and treatment approaches in triple-negative breast cancer

Yueyuan Zhou

, 1 more and

Wei Zhu

2,555 views

6 citations

Review

31 August 2022

Applying artificial intelligence technology to assist with breast cancer diagnosis and prognosis prediction

Meredith A. Jones

, 3 more and

Bin Zheng

Breast cancer remains the most diagnosed cancer in women. Advances in medical imaging modalities and technologies have greatly aided in the early detection of breast cancer and the decline of patient mortality rates. However, reading and interpreting breast images remains difficult due to the high heterogeneity of breast tumors and fibro-glandular tissue, which results in lower cancer detection sensitivity and specificity and large inter-reader variability. In order to help overcome these clinical challenges, researchers have made great efforts to develop computer-aided detection and/or diagnosis (CAD) schemes of breast images to provide radiologists with decision-making support tools. Recent rapid advances in high throughput data analysis methods and artificial intelligence (AI) technologies, particularly radiomics and deep learning techniques, have led to an exponential increase in the development of new AI-based models of breast images that cover a broad range of application topics. In this review paper, we focus on reviewing recent advances in better understanding the association between radiomics features and tumor microenvironment and the progress in developing new AI-based quantitative image feature analysis models in three realms of breast cancer: predicting breast cancer risk, the likelihood of tumor malignancy, and tumor response to treatment. The outlook and three major challenges of applying new AI-based models of breast images to clinical practice are also discussed. Through this review we conclude that although developing new AI-based models of breast images has achieved significant progress and promising results, several obstacles to applying these new AI-based models to clinical practice remain. Therefore, more research effort is needed in future studies.

9,343 views

29 citations

Original Research

19 August 2022

Anxiety and depression risk in Taiwan women with breast cancer and cervical cancer

Chiu-Ming Yang

, 4 more and

Shwn-Huey Shieh

3,214 views

12 citations

PCBP2 can directly bind 3’UTR of UFD1 and NT5E, positively regulate their transcripts,and promote tumor growth and metastasis. Lnc030 cooperates with PCBP2 to stabilize SQLE mRNA, increase cholesterol synthesis, activate PI3K/Akt signal transduction, and regulate cholesterol synthesis and stemness properties of BCSCs. Arrows indicate activation and blunted lines indicate inhibition.

Review

18 August 2022

Research progress on RNA−binding proteins in breast cancer

Ying Chen

, 1 more and

Lufeng Zheng

3,801 views

12 citations

These strategies may involve RNA-protein or protein-protein interactions, cellular pathways and protein aggregation, among others. Direct therapeutic strategies revolve around knocking down or overexpressing specific RBPs, while indirect approaches, on the other hand, include the use of small molecules, oligonucleotide-based strategies (ASO, SiRNA, Aptamer) and other potential strategies. The schematic diagram lists some of the RBPs that have made breakthroughs in breast cancer treatment strategy research.

Review

16 August 2022

The function and regulatory mechanism of RNA-binding proteins in breast cancer and their future clinical treatment prospects

Xingjia Lu

, 9 more and

Fei Ge

4,322 views

11 citations

MaSCs expose to mutations that cause abnormal differentiation and transformation into cancer stem cells. A comparison between specific molecular features of normal breast epithelial subpopulations and different breast cancer subtypes revealed that the tumor subtypes appeared to have similar differentiation characteristics to normal breast cells.

Review

15 August 2022

Fate decisions of breast cancer stem cells in cancer progression

Hui Xu

, 3 more and

Linhai Zhu

3,256 views

10 citations

Original Research

03 August 2022

Research trends and hotspots of breast cancer management during the COVID-19 pandemic: A bibliometric analysis

Peng-fei Lyu

, 4 more and

Xu-Chen Cao

3,294 views

6 citations

Mini Review

02 August 2022

Sexual dysfunction as a challenge in treated breast cancer: in-depth analysis and risk assessment to improve individual outcomes

Abraham Hernández-Blanquisett

, 3 more and

Raissa Diaz-Cáceres

4,063 views

15 citations

Review

18 July 2022

Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer

Carlos Alexander Huertas-Caro

, 3 more and

Silvia J. Serrano-Gómez

4,375 views

14 citations

Review

18 July 2022

IL-6: The Link Between Inflammation, Immunity and Breast Cancer

Juan Chen

, 5 more and

Jiawei Chen

Breast cancer is one of the leading causes of mortality in females. Over the past decades, intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin-6 (IL-6) is a pleiotropic factor which has a vital role in host defense immunity and acute stress. Moreover, a wide range of studies have identified the physiological and pathological roles of IL-6 in inflammation, immune and cancer. Recently, several IL-6 signaling pathway-targeted monoclonal antibodies have been developed for cancer and immune therapy. Combination of IL-6 inhibitory antibody with other pathways blockage drugs have demonstrated promising outcome in both preclinical and clinical trials. This review focuses on emerging studies on the strong linkages of IL-6/IL-6R mediated regulation of inflammation and immunity in cancer, especially in breast cancer.

10,514 views

69 citations