Zebrafish is one of the popular models to study embryonic development and model human congenital disorders. The zebrafish genome has been sequenced and large number of genetic maps are available. Many mutant transgenic lines are available to identify novel genes during embryogenesis and used as models to study pathophysiology of various congenital diseases. Further, the zebrafish is widely used for large, high throughput screening of potential therapeutic compounds. The zebrafish has an extensive genetic toolkit and technological advances like CRISPR and NGS enable the modeling of human diseases at the sub-cellular resolution.
Zebrafish as a model for human diseases has immense, untapped potential. A thorough comparative analysis of the fish genome and physiology with respect to humans is imperative to gain clinical relevance of this model for human diseases. The zebrafish model will be a promising platform for precision medicine initiatives for many human disorders. In this issue, we invite articles from different fields of biology which implement zebrafish as a key tool to uncover the secrets of embryonic development and the associated congenital diseases.
• Modelling human congenital hematopoietic and cardiovascular diseases
• Zebrafish as a model for neurodevelopment and neuronal function
• Zebrafish as a model for metabolic diseases
• Modelling cancer using zebrafish
• Forward & reverse genetic approaches to generate zebrafish disease models
• Technical advances in genetic engineering using zebrafish
• Article types: reviews, perspectives, research articles, hypothesis, primers
Zebrafish is one of the popular models to study embryonic development and model human congenital disorders. The zebrafish genome has been sequenced and large number of genetic maps are available. Many mutant transgenic lines are available to identify novel genes during embryogenesis and used as models to study pathophysiology of various congenital diseases. Further, the zebrafish is widely used for large, high throughput screening of potential therapeutic compounds. The zebrafish has an extensive genetic toolkit and technological advances like CRISPR and NGS enable the modeling of human diseases at the sub-cellular resolution.
Zebrafish as a model for human diseases has immense, untapped potential. A thorough comparative analysis of the fish genome and physiology with respect to humans is imperative to gain clinical relevance of this model for human diseases. The zebrafish model will be a promising platform for precision medicine initiatives for many human disorders. In this issue, we invite articles from different fields of biology which implement zebrafish as a key tool to uncover the secrets of embryonic development and the associated congenital diseases.
• Modelling human congenital hematopoietic and cardiovascular diseases
• Zebrafish as a model for neurodevelopment and neuronal function
• Zebrafish as a model for metabolic diseases
• Modelling cancer using zebrafish
• Forward & reverse genetic approaches to generate zebrafish disease models
• Technical advances in genetic engineering using zebrafish
• Article types: reviews, perspectives, research articles, hypothesis, primers