The formation of the placenta is a very complex process involving maternal components and other derivatives of the embryo/fetus. Placentation has great temporal variations, but also an enormous diversity among different species of placental animals. Various previously existing cell populations (uterine fibroblasts, NK cells) change morphologically and functionally; but, in addition, others appear only at this point of ontogeny, such as the different types of trophoblastic cells. For those mentioned cell types and others (lymphocytes, endothelial cells, uterine epithelium, etc.) cell proliferation, death and differentiation are modified during placentations. Some cells synthesize substances found exclusively in the placenta. Epigenetic processes such as imprinting are manifested more in placental cells than in those located in other tissues. The complexity of placental morphogenesis explains the diversity of alterations that can occur as a consequence of cellular and molecular changes.
Understanding placental morphogenesis in its diversity and how it is altered in different pathological situations requires the integration of knowledge derived from different lines of research. The study of the cellular and molecular processes that occur during placentation requires a multidisciplinary analysis, based on different methodological approaches that analyze the different levels of organization. But it must also include placental diversity. Despite the numerous papers that have been recently published, the understanding of the normal processes of placentation and its alteration in situations such as preeclampsia permanently requires new studies and reviews that bring together the knowledge arising from the different lines. The objective of this research topic is to gather the results of some of these new studies.
The scope of the research topic includes:
-Trophoblast biology
-Decidualization
-Immunology of implantation and placentation
-Placental angiogenesis
-Cell kinetics during placentation
-Exchange of substances across the placental barrier
-Endocrinology of placentation
-Epigenetic changes in the placenta and its relationship with assisted reproductive techniques in humans and domestic animals
-Diversity and placental evolution
-Cellular and molecular bases of placental pathology in humans, in experimental models and in domestic animals
Different types of articles will be accepted including: Original research, Reviews, Minireviews and Hypothesis and Theory.
The formation of the placenta is a very complex process involving maternal components and other derivatives of the embryo/fetus. Placentation has great temporal variations, but also an enormous diversity among different species of placental animals. Various previously existing cell populations (uterine fibroblasts, NK cells) change morphologically and functionally; but, in addition, others appear only at this point of ontogeny, such as the different types of trophoblastic cells. For those mentioned cell types and others (lymphocytes, endothelial cells, uterine epithelium, etc.) cell proliferation, death and differentiation are modified during placentations. Some cells synthesize substances found exclusively in the placenta. Epigenetic processes such as imprinting are manifested more in placental cells than in those located in other tissues. The complexity of placental morphogenesis explains the diversity of alterations that can occur as a consequence of cellular and molecular changes.
Understanding placental morphogenesis in its diversity and how it is altered in different pathological situations requires the integration of knowledge derived from different lines of research. The study of the cellular and molecular processes that occur during placentation requires a multidisciplinary analysis, based on different methodological approaches that analyze the different levels of organization. But it must also include placental diversity. Despite the numerous papers that have been recently published, the understanding of the normal processes of placentation and its alteration in situations such as preeclampsia permanently requires new studies and reviews that bring together the knowledge arising from the different lines. The objective of this research topic is to gather the results of some of these new studies.
The scope of the research topic includes:
-Trophoblast biology
-Decidualization
-Immunology of implantation and placentation
-Placental angiogenesis
-Cell kinetics during placentation
-Exchange of substances across the placental barrier
-Endocrinology of placentation
-Epigenetic changes in the placenta and its relationship with assisted reproductive techniques in humans and domestic animals
-Diversity and placental evolution
-Cellular and molecular bases of placental pathology in humans, in experimental models and in domestic animals
Different types of articles will be accepted including: Original research, Reviews, Minireviews and Hypothesis and Theory.