Even though 3'-5'-cyclic adenosine monophosphate (cAMP) was discovered more than half a century ago, it still remains an object of scientific interest. And this is not surprising, since cAMP signaling plays a vital role in a wide variety of physiological processes, e.g., transcriptional regulation, metabolism, cell-cell junction stability and barrier properties of endothelial and epithelial cells, mitochondrial homeostasis, cell migration, as well as cell growth and cell death. The importance of cAMP signaling is further underlined by the fact that this pathway is evolutionarily conserved and can be found in all species from microorganisms to mammals.
In the last decade, cAMP research revealed well-organized compartmentation of the cAMP signaling within the cell providing its spatial and temporal specificity and selectivity. First, this compartmentalization is achieved by the distinct spatial distribution of the two main types of cAMP-generating enzymes, i.e., membrane-bound adenylyl cyclases and soluble adenylyl cyclase (sAC), which is localized within various cellular compartments. Furthermore, phosphodiesterases (PDEs) and A-kinase anchoring proteins (AKAPs), also contribute to the subcellular compartmentalization of cAMP signaling.
Aside from the intracellular role of cAMP as a second messenger, the emerging role of cAMP e?ux and the extracellular cAMP-adenosine pathway has also been suggested.
cAMP signaling has been and still is an important target for therapeutic intervention in various human diseases. Adrenergic beta 1 antagonists in hypertension and beta 2 agonists in airways pathology have been in clinical use for decades. Likewise, prostaglandin I2 (PGI2) and its analogues are clinically used in pulmonary hypertension and are currently being tested for potential use in wound healing. Various PDEs are being tested for therapeutic use in asthma, inflammatory diseases, and neural disorders. Resveratrol as a potential PDE inhibitor is currently investigated for potential use to ameliorate aging-related pathologies.
With this Research Topic we are looking for manuscripts on research related to cAMP signaling in basic sciences and investigating the translational aspects as well as researchers developing novel methods to study cAMP signaling to submit their work in this Research Topic. Authors are welcome to submit manuscripts in all areas of current cAMP research with an emphasis on basic as well as translational aspects. Particularly, studies addressing the role of cAMP in diseases and aging are explicitly encouraged. The Research Topic welcomes up-to-date hypotheses, reviews, research articles, and short communications. Computational modeling studies, if relevant, are also welcome.
Even though 3'-5'-cyclic adenosine monophosphate (cAMP) was discovered more than half a century ago, it still remains an object of scientific interest. And this is not surprising, since cAMP signaling plays a vital role in a wide variety of physiological processes, e.g., transcriptional regulation, metabolism, cell-cell junction stability and barrier properties of endothelial and epithelial cells, mitochondrial homeostasis, cell migration, as well as cell growth and cell death. The importance of cAMP signaling is further underlined by the fact that this pathway is evolutionarily conserved and can be found in all species from microorganisms to mammals.
In the last decade, cAMP research revealed well-organized compartmentation of the cAMP signaling within the cell providing its spatial and temporal specificity and selectivity. First, this compartmentalization is achieved by the distinct spatial distribution of the two main types of cAMP-generating enzymes, i.e., membrane-bound adenylyl cyclases and soluble adenylyl cyclase (sAC), which is localized within various cellular compartments. Furthermore, phosphodiesterases (PDEs) and A-kinase anchoring proteins (AKAPs), also contribute to the subcellular compartmentalization of cAMP signaling.
Aside from the intracellular role of cAMP as a second messenger, the emerging role of cAMP e?ux and the extracellular cAMP-adenosine pathway has also been suggested.
cAMP signaling has been and still is an important target for therapeutic intervention in various human diseases. Adrenergic beta 1 antagonists in hypertension and beta 2 agonists in airways pathology have been in clinical use for decades. Likewise, prostaglandin I2 (PGI2) and its analogues are clinically used in pulmonary hypertension and are currently being tested for potential use in wound healing. Various PDEs are being tested for therapeutic use in asthma, inflammatory diseases, and neural disorders. Resveratrol as a potential PDE inhibitor is currently investigated for potential use to ameliorate aging-related pathologies.
With this Research Topic we are looking for manuscripts on research related to cAMP signaling in basic sciences and investigating the translational aspects as well as researchers developing novel methods to study cAMP signaling to submit their work in this Research Topic. Authors are welcome to submit manuscripts in all areas of current cAMP research with an emphasis on basic as well as translational aspects. Particularly, studies addressing the role of cAMP in diseases and aging are explicitly encouraged. The Research Topic welcomes up-to-date hypotheses, reviews, research articles, and short communications. Computational modeling studies, if relevant, are also welcome.