Neuronal functionality is orchestrated by critical molecular events, and their integrity is essential in the proper functioning and organization of the developing brain. Developmental neurogenesis comprises several molecular events, such as cellular plasticity, growth, migration, survival. In developing brains, the lack of appropriate neural circuits disrupts neuronal functions, which results in scenarios like epilepsy and seizures. Moreover, several developmental disorders such as lissencephaly, autism, periventricular heterotopia are directly linked to defects in neocortex formation. The targeted therapies related to those disorders experience various challenges due to incomplete knowledge of neurodevelopment mechanisms. This Research Topic will elucidate novel molecular pathways concerning neuronal development and associated diseases.
Our principal focus is on signaling molecules that define the cellular identities and key molecular switches linked to neuro-developmental phenotypes and disorders in experimental model systems. This study focused on the specific molecular events and the pathways affected in brain development. The development of exclusively targeted therapeutics for these conditions encounters various challenges that include the nonexsistence of biomarkers for initial detection and progression, complex molecular mechanisms, heterogeneous phenotypes.
Topics of interest in this Research Topic include but are not limited to:
1) Identification of novel molecular events in neo-natal neurogenesis.
2) Identification of the role of a molecular signal in neurodevelopment-related disorders.
3) Developing novel targeted therapy and/or treatment strategies for neurodevelopmental disorders.
4) Effect of novel micro/noncoding RNAs in neurodevelopment and as treatment strategies for neurodevelopment-related disorders.
Neuronal functionality is orchestrated by critical molecular events, and their integrity is essential in the proper functioning and organization of the developing brain. Developmental neurogenesis comprises several molecular events, such as cellular plasticity, growth, migration, survival. In developing brains, the lack of appropriate neural circuits disrupts neuronal functions, which results in scenarios like epilepsy and seizures. Moreover, several developmental disorders such as lissencephaly, autism, periventricular heterotopia are directly linked to defects in neocortex formation. The targeted therapies related to those disorders experience various challenges due to incomplete knowledge of neurodevelopment mechanisms. This Research Topic will elucidate novel molecular pathways concerning neuronal development and associated diseases.
Our principal focus is on signaling molecules that define the cellular identities and key molecular switches linked to neuro-developmental phenotypes and disorders in experimental model systems. This study focused on the specific molecular events and the pathways affected in brain development. The development of exclusively targeted therapeutics for these conditions encounters various challenges that include the nonexsistence of biomarkers for initial detection and progression, complex molecular mechanisms, heterogeneous phenotypes.
Topics of interest in this Research Topic include but are not limited to:
1) Identification of novel molecular events in neo-natal neurogenesis.
2) Identification of the role of a molecular signal in neurodevelopment-related disorders.
3) Developing novel targeted therapy and/or treatment strategies for neurodevelopmental disorders.
4) Effect of novel micro/noncoding RNAs in neurodevelopment and as treatment strategies for neurodevelopment-related disorders.