It is broadly accepted that one of the hallmarks of the aging process is the reduction of immunological activities, a phenomenon named immunosenescence, which is considered a corollary factor that leads the older population to present decreased immune responses to both infection and vaccination. Another aging-related phenomena known as inflamm-aging, which is characterized by chronic, systemic, sterile low-grade inflammation in which pro-inflammatory cytokine levels rise with age, might be regarded as a cornerstone for immunosenescence development.
Recent evidence suggests that latent chronic infection by a variety of microorganisms might affect the control of the inflammatory state in older adults, resulting in inflamm-aging and immunosenescence in this population.
This Research Topic aims to discuss the role of latent chronic infection in immunosenescence and inflamm-aging. It also aims to discuss how the specific species of microorganisms may be important in the development of immunosenescence and inflamm-aging. As a result, the submission of manuscripts focusing on the impact of latent chronic infection in various immune/inflammatory response contexts (e.g. mucosal immunity, vaccination, autoimmune diseases, immunodeficiencies, dysbiosis, among others) in older adults will be welcome.
We welcome the submission of Original Research manuscripts, Reviews, Mini Reviews focusing on any of the following themes:
(1) Innate and adaptative immune systems in latent chronic infection in older adults - friends or foes?
(2) Impact of pathogenic and probiotic agents on the mucosal immunity during the aging process
(3) Influence of latent chronic viral infection on vaccination responses in older adults, particularly to influenza and COVID-19 vaccines.
(4) Can cycles of latent chronic infection reactivation drive and/or accelerate inflamm-aging and immunosenescence?
(5) Impact of latent chronic infection on metabolic, neurologic, autoimmune diseases, and immunodeficiencies in older adults
(6) Can latent chronic infection affect the development of inflamm-aging and immunosenescence differentially in aging women and men?
(7) How may latent chronic infection be mitigated or minimized in the development of inflamm-aging and immunosenescence in older adults?
It is broadly accepted that one of the hallmarks of the aging process is the reduction of immunological activities, a phenomenon named immunosenescence, which is considered a corollary factor that leads the older population to present decreased immune responses to both infection and vaccination. Another aging-related phenomena known as inflamm-aging, which is characterized by chronic, systemic, sterile low-grade inflammation in which pro-inflammatory cytokine levels rise with age, might be regarded as a cornerstone for immunosenescence development.
Recent evidence suggests that latent chronic infection by a variety of microorganisms might affect the control of the inflammatory state in older adults, resulting in inflamm-aging and immunosenescence in this population.
This Research Topic aims to discuss the role of latent chronic infection in immunosenescence and inflamm-aging. It also aims to discuss how the specific species of microorganisms may be important in the development of immunosenescence and inflamm-aging. As a result, the submission of manuscripts focusing on the impact of latent chronic infection in various immune/inflammatory response contexts (e.g. mucosal immunity, vaccination, autoimmune diseases, immunodeficiencies, dysbiosis, among others) in older adults will be welcome.
We welcome the submission of Original Research manuscripts, Reviews, Mini Reviews focusing on any of the following themes:
(1) Innate and adaptative immune systems in latent chronic infection in older adults - friends or foes?
(2) Impact of pathogenic and probiotic agents on the mucosal immunity during the aging process
(3) Influence of latent chronic viral infection on vaccination responses in older adults, particularly to influenza and COVID-19 vaccines.
(4) Can cycles of latent chronic infection reactivation drive and/or accelerate inflamm-aging and immunosenescence?
(5) Impact of latent chronic infection on metabolic, neurologic, autoimmune diseases, and immunodeficiencies in older adults
(6) Can latent chronic infection affect the development of inflamm-aging and immunosenescence differentially in aging women and men?
(7) How may latent chronic infection be mitigated or minimized in the development of inflamm-aging and immunosenescence in older adults?