Case Reports in Pediatric Hematology and Hematological Malignancies 2022

Editorial

28 July 2023

Editorial: Case reports in pediatric hematology and hematological malignancies 2022

Paulo S. S. Santos

Hasan Hashem

and

Daniele Zama

1,130 views

0 citations

Editors

Daniele Zama

Sant'Orsola-Malpighi Polyclinic

Hasan Hashem

King Hussein Cancer Center

Hamidah Alias

Department of Pediatrics, Faculty of Medicine, National University of Malaysia

Paulo Sérgio da Silva Santos

Faculty of Dentistry of Bauru, University of São Paulo

Impact

Case Report

01 March 2023

Case report: Tisagenlecleucel for treatment of relapsed B- acute lymphoblastic leukemia in a patient with CHEK2 mutation

Abraham Ipe

, 5 more and

Anant Vatsayan

3,317 views

0 citations

Cartoon showing a schematic representation of chromosomes 9 (blue) and 14 (yellow) at the derivative chromosomes 9 and 14 (upper panel), the black squares mark the junctions. Middle cartoon represents a blow up of the junctions illustrating the creation of the fusion gene on derivative chromosome 9 (der9). The lower panel represents a magnification of the fusion gene showing exons 1–25 in CCDC88C joined to exons 16–25 in JAK2.

Case Report

10 January 2023

Case Report: Whole genome sequencing identifies CCDC88C as a novel JAK2 fusion partner in pediatric T-cell acute lymphoblastic leukemia

Aleksandra Krstic

, 4 more and

Gisela Barbany

1,497 views

3 citations

Case Report

09 January 2023

Case report: Venetoclax therapy in a boy with acute myeloid leukemia in Shwachman Diamond syndrome

Samuele Naviglio

, 7 more and

Marco Rabusin

2,934 views

5 citations

Case Report

22 December 2022

Case report: “Congenital cutaneous langerhans cell histiocytosis presenting with blueberry Muffin Rash”

Mariam Thalji

, 6 more and

Motee Abuawaad

3,465 views

1 citations

(A) Bone marrow aspirate showing mostly eosinophils, Wright–Giemsa stain, 40×. (B) Biopsy from the orbital mass demonstrating heavy lymphoid infiltrate composed of small- to medium-sized lymphoblasts, hematoxylin and eosin stain, 40×. (C,D) PAX5 and TdT immunostains showing positive brown nuclear stain in the tumor cells, respectively, indicating that these cells are B-cell lymphoblasts 40×. (E) Rearranged PDGFRA gene (arrows). Rearrangement results from fusion of FIPL1 and PDGFRA after CHIC2 deletion.

Case Report

14 December 2022

Case Report: Pediatric myeloid/lymphoid neoplasm with eosinophilia and PDGFRA rearrangement: The first case presenting as B-lymphoblastic lymphoma

Reem Akiely

, 2 more and

Amal Abu-Ghosh

2,646 views

2 citations

Synopsis of the clinical course and treatment. HSCT, hematopoietic stem cell transplantation; ATG, antithymocyte globulin; CSA, ciclosporin A; CMV, cytomegalovirus.

Case Report

02 December 2022

Splenic rupture and fungal endocarditis in a pediatric patient with invasive fusariosis after allogeneic hematopoietic stem cell transplantation for aplastic anemia: A case report

Maurice Hannemann

, 10 more and

Karoline Ehlert

2,382 views

1 citations

Case Report

21 September 2022

Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl

Ya Bin Zhou

, 2 more and

Rui Hui Wu

11,081 views

3 citations

Original Research

07 November 2022

Pediatric immune myelofibrosis (PedIMF) as a novel and distinct clinical pathological entity

Fabiola Guerra

, 10 more and

Francesco Saettini

2,734 views

3 citations

(A) Increased immature/transitional B in the peripheral blood (upper panel; in red are represented CD10+CD21–CD27– transitional or immature B cells, in green CD10–CD21–CD27+ terminally differentiated B cells) and bone marrow (lower panel; in green CD34+CD38+CD10+). (B) Peripheral blood smears showing JMML in P1 (left panel): leukocytosis with monocytosis (triangle) and myeloid precursors (arrows). In the right panel, anisocytosis of platelets without leukocytosis or monocytosis in P2’s peripheral blood smear. (C) CytoScan HD Array (SNP) analysis: allelic peak (AP) graph showing large copy neutral (CN = 2) loss of heterozygosity (LOH) regions in long arm of chromosome 11, in both patients; common LOH region includes CBL gene at band 11q23.3 (red line). (D) DNA methylation patterns in the reported patients showing low-methylation status. (E) STAT5 phosphorylation consistent with JMML in P1. AP, allele peaks; CHR, chromosome; CN, copy number state; HC, healthy control; IM, intermediate methylation; HM, high methylation; LM, low methylation; LOH, loss of heterozygosity; MRK, markers/markers number; P1 and P2, patients, START/END, cytoband start/end.

Case Report

28 July 2022

Abnormal B-Cell Maturation and Increased Transitional B Cells in CBL Syndrome

Francesco Saettini

, 13 more and

Andrea Biondi

2,530 views

5 citations

Hematopoietic stem/progenitor cell (HPSC) origin of the IgH rearranged common lymphoid committed tumor progenitor (LCP). Acquisition of different driver mutations may contribute to the development of the B-ALL and IDCS clones. Created with BioRender.com.

Case Report

16 September 2022

Potential role of MAP2K1 mutation in the trans-differentiation of interdigitating dendritic cell sarcoma: Case report and literature review

Alex Jenei

, 5 more and

Ágota Szepesi

2,540 views

2 citations

Patient's clinical course and treatment for juvenile myelomonocytic leukemia and complications. Tac, tacrolimus; PSL, prednisolone; 6-MP, 6-mercaptopurine; HSCT, hematopoietic stem cell transplantation; OTCD, ornithine transcarbamylase deficiency.

Case Report

06 May 2022

Case Report: Juvenile Myelomonocytic Leukemia Underlying Ornithine Transcarbamylase Deficiency Safely Treated Using Hematopoietic Stem Cell Transplantation

Hiroi Eguchi

, 5 more and

Muneaki Matsuo

3,184 views

1 citations

Case Report

20 September 2022

Case report: A case of acquired von Willebrand syndrome as onset clinical presentation of systemic lupus erythematosus manifested as epistaxis and pulmonary hemorrhage

Songmi Wang

, 5 more and

Aiguo Liu

2,845 views

1 citations

Case Report

Frontiers in Pediatrics

Immune dysregulation in Kabuki syndrome: a case report of Evans syndrome and hypogammaglobulinemia

Lucia Leonardi

, 10 more and

Luigi Tarani

0 views

0 citations

Open for submission

Frontiers in Pediatrics

Diagnosis and Therapy Pediatric Hematological Malignancies - Recent Progress - Volume II

Edited by Joanna Zawitkowska, Monika Lejman, Katarzyna Derwich

Deadline

02 May 2025

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