Neonatal physiological jaundice is a common clinical finding and mostly resolves spontaneously within the first 2 weeks of life. However, prolonged jaundice beyond the age of 2 to 3 weeks is abnormal. Cholestasis in neonates and infants has numerous causes, including infections, anatomic abnormalities of the biliary system, endocrinopathies, genetic disorders, metabolic abnormalities, toxin and drug exposures, vascular abnormalities, neoplastic processes, and others. If left untreated, cholestasis results in chronic hepatic dysfunction, which can lead to the necessity of liver transplantation and possibly death. Therefore, it is essential to rapidly identify treatable cholestasis such as biliary atresia or congenital biliary dilatation. For early detection of cholestasis, prompt diagnostic evaluation, and adequate treatment, comprehensive expertise is required. Moreover, for surgery of biliary atresia or congenital biliary atresia, highly advanced surgical techniques are necessary. However, the etiology of neonatal cholestasis varies, and each incidence is low; thus, evidence-based strategies have not been fully established yet for any cholestatic disease. Pediatric surgeons need to update their insights into the recent advances in both diagnostic and treatment strategies for cholestasis in infancy.
Our goal for this Research Topic is to collect high-quality studies regarding cholestasis in infancy and provide an opportunity to gather recent insights into the condition.
We welcome contributions of Original Research, Operative Technique, Clinical Images, Systematic Review, Perspective, Clinical Trial, Case Report, General Commentary, and Clinical, Translational, and Basic Research focusing on, but not limited to, the following aspects:
・Differential diagnosis of neonatal cholestasis
・Nonsurgical neonatal cholestatic disorders such as progressive familial intrahepatic cholestasis
・Diagnosis and treatment of biliary atresia
・Surgical techniques and outcomes of congenital biliary dilatation
Neonatal physiological jaundice is a common clinical finding and mostly resolves spontaneously within the first 2 weeks of life. However, prolonged jaundice beyond the age of 2 to 3 weeks is abnormal. Cholestasis in neonates and infants has numerous causes, including infections, anatomic abnormalities of the biliary system, endocrinopathies, genetic disorders, metabolic abnormalities, toxin and drug exposures, vascular abnormalities, neoplastic processes, and others. If left untreated, cholestasis results in chronic hepatic dysfunction, which can lead to the necessity of liver transplantation and possibly death. Therefore, it is essential to rapidly identify treatable cholestasis such as biliary atresia or congenital biliary dilatation. For early detection of cholestasis, prompt diagnostic evaluation, and adequate treatment, comprehensive expertise is required. Moreover, for surgery of biliary atresia or congenital biliary atresia, highly advanced surgical techniques are necessary. However, the etiology of neonatal cholestasis varies, and each incidence is low; thus, evidence-based strategies have not been fully established yet for any cholestatic disease. Pediatric surgeons need to update their insights into the recent advances in both diagnostic and treatment strategies for cholestasis in infancy.
Our goal for this Research Topic is to collect high-quality studies regarding cholestasis in infancy and provide an opportunity to gather recent insights into the condition.
We welcome contributions of Original Research, Operative Technique, Clinical Images, Systematic Review, Perspective, Clinical Trial, Case Report, General Commentary, and Clinical, Translational, and Basic Research focusing on, but not limited to, the following aspects:
・Differential diagnosis of neonatal cholestasis
・Nonsurgical neonatal cholestatic disorders such as progressive familial intrahepatic cholestasis
・Diagnosis and treatment of biliary atresia
・Surgical techniques and outcomes of congenital biliary dilatation