Chronic inflammatory diseases such as cardiovascular diseases, obesity, and inflammatory bowel diseases are increasing dramatically and may lead to development of organ fibrosis. Accumulating evidence highlights the critical role of diet in the regulation of these processes. Among these potential regulatory mechanisms, epigenetic modifications are at a crossroads between diet, inflammation, and fibrosis. Understanding fibrosis processes at a molecular and cellular level can help to develop novel therapies in addressing this unmet need. As fibrotic processes involve a wide variety of cells, their specific roles have to be better characterized. Hence, molecular and cellular mechanisms behind organ fibrosis should be explored to develop novel therapeutic strategies.
Development of fibrosis involves many signalling pathways and numerous cells from various origins. This complicates the understanding of this process and the identification of relevant therapeutic targets, and consequently, fibrosis treatment of most organs remains an unmet need. This Research Topic aims to better understand how diet and/or epigenetics may influence multi-organ chronic immune responses and subsequent fibrosis. Particular interest will be paid to cell-specific regulation of fibrosis.
The scope of this Research Topic is to publish high-quality, up-to-date scientific reports related to nutritional regulation of immune response and fibrosis, particularly in the context of chronic diseases. Particular interest will be paid to modulation of epigenetic modifications by nutritional behaviours and/or contents. We welcome submissions of original research articles, letters, reviews, mini-reviews, and short communications, with subtopics of interest including, but not limited to:
• Nutritional impact on fibrosis of various organs;
• Nutritional modulation of epigenetic mechanisms of fibrosis;
• Immune cell fate commitment and organ fibrosis regulation;
• Interplay between fibrotic organs and others;
• Dysfunctional and/or malnutritional consequences on immune response and cellular fibrosis;
• Cell-specific mechanisms underlying fibrosis development;
• Novel molecular mechanisms for treating fibrosis.
Chronic inflammatory diseases such as cardiovascular diseases, obesity, and inflammatory bowel diseases are increasing dramatically and may lead to development of organ fibrosis. Accumulating evidence highlights the critical role of diet in the regulation of these processes. Among these potential regulatory mechanisms, epigenetic modifications are at a crossroads between diet, inflammation, and fibrosis. Understanding fibrosis processes at a molecular and cellular level can help to develop novel therapies in addressing this unmet need. As fibrotic processes involve a wide variety of cells, their specific roles have to be better characterized. Hence, molecular and cellular mechanisms behind organ fibrosis should be explored to develop novel therapeutic strategies.
Development of fibrosis involves many signalling pathways and numerous cells from various origins. This complicates the understanding of this process and the identification of relevant therapeutic targets, and consequently, fibrosis treatment of most organs remains an unmet need. This Research Topic aims to better understand how diet and/or epigenetics may influence multi-organ chronic immune responses and subsequent fibrosis. Particular interest will be paid to cell-specific regulation of fibrosis.
The scope of this Research Topic is to publish high-quality, up-to-date scientific reports related to nutritional regulation of immune response and fibrosis, particularly in the context of chronic diseases. Particular interest will be paid to modulation of epigenetic modifications by nutritional behaviours and/or contents. We welcome submissions of original research articles, letters, reviews, mini-reviews, and short communications, with subtopics of interest including, but not limited to:
• Nutritional impact on fibrosis of various organs;
• Nutritional modulation of epigenetic mechanisms of fibrosis;
• Immune cell fate commitment and organ fibrosis regulation;
• Interplay between fibrotic organs and others;
• Dysfunctional and/or malnutritional consequences on immune response and cellular fibrosis;
• Cell-specific mechanisms underlying fibrosis development;
• Novel molecular mechanisms for treating fibrosis.