Psychiatric disorders are the leading cause of disability worldwide and seriously impact health, society, and the economy. Despite the wide range of available treatments to minimize the suffering experienced by psychiatric patients, there is a high percentage of non-responders. Additionally, while most available pharmacological treatments directly target neurotransmission systems previously associated with psychiatric etiology, our understanding of the pathophysiology of psychiatric diseases remains incomplete. Serendipity and experimental evidence led to the current predominance of serotoninergic, dopaminergic, GABAergic, and lithium-based drugs, but several studies have described the ability of psychiatric drugs to modulate systems other than the CNS by having immune, antioxidant, neuroplastic, epigenetic, and microbiome effects. Unraveling their different actions beyond neurotransmission could shed light not only on new mechanistic approaches to develop new treatment, but also on relevant features of psychiatric pathophysiology that remain elusive.
This Resarch Topic focuses on the non-canonical effects of psychiatric drugs beyond their neurotransmitter modulation. Thus, we invite researchers to contribute original work related to this research topic, including but not limited to immunomodulatory, antioxidant, epigenetic, and microbiome properties of antidepressants, antipsychotics, or any other drug used in the treatment of psychiatric disorders. Reviews and meta-analyses collecting strong evidence of their actions are also welcome. Moreover, any new ideas, integrative theories, and directions for the future development of psychiatric drugs can also be helpful to delve into the pathophysiology of psychiatric disorders.
This Research Topic welcomes themes associated with the effects of:
• Antidepressants
• Antipsychotics
• Anxiolytics
• Mood stabilizers
• Stimulants
on different biological processes beyond their neurotransmitter action, especially including but not limited to immunology, antioxidant system, neuroplasticity, epigenetics, and the microbiome.
Psychiatric disorders are the leading cause of disability worldwide and seriously impact health, society, and the economy. Despite the wide range of available treatments to minimize the suffering experienced by psychiatric patients, there is a high percentage of non-responders. Additionally, while most available pharmacological treatments directly target neurotransmission systems previously associated with psychiatric etiology, our understanding of the pathophysiology of psychiatric diseases remains incomplete. Serendipity and experimental evidence led to the current predominance of serotoninergic, dopaminergic, GABAergic, and lithium-based drugs, but several studies have described the ability of psychiatric drugs to modulate systems other than the CNS by having immune, antioxidant, neuroplastic, epigenetic, and microbiome effects. Unraveling their different actions beyond neurotransmission could shed light not only on new mechanistic approaches to develop new treatment, but also on relevant features of psychiatric pathophysiology that remain elusive.
This Resarch Topic focuses on the non-canonical effects of psychiatric drugs beyond their neurotransmitter modulation. Thus, we invite researchers to contribute original work related to this research topic, including but not limited to immunomodulatory, antioxidant, epigenetic, and microbiome properties of antidepressants, antipsychotics, or any other drug used in the treatment of psychiatric disorders. Reviews and meta-analyses collecting strong evidence of their actions are also welcome. Moreover, any new ideas, integrative theories, and directions for the future development of psychiatric drugs can also be helpful to delve into the pathophysiology of psychiatric disorders.
This Research Topic welcomes themes associated with the effects of:
• Antidepressants
• Antipsychotics
• Anxiolytics
• Mood stabilizers
• Stimulants
on different biological processes beyond their neurotransmitter action, especially including but not limited to immunology, antioxidant system, neuroplasticity, epigenetics, and the microbiome.