This Research Topic aims to provide a mechanistic view on how the Central Nervous System (CNS), in response to stresses, incurs phenotypical changes by regulated changes in the so-called nascent proteome –proteome consisting of newly synthesized proteins within a time window. Among many components or aspects of a proteome, the nascent proteome affords a description of response-in-action, when stressed cells attempt to maintain or reset the proteostasis. Both biosynthesis and degradation of proteins contribute to proteostasis. However, proteome-wide, the former has a higher degree of selectivity than the latter, especially when cellular conditions become deteriorating.
Principally, proteomes not only manifest the execution but also provide revisions of genomic instruction. The poor correlation between levels of proteins and gene transcripts (<0.4 on average) has long been noted. Thanks to the recent advancement in proteomic, transcriptomic, and bioinformatics technologies, this phenomenon is now recognized Ome-wide. This knowledge argues that characteristics of a proteome cannot be readily extrapolated from genomic or transcriptomic characterization, but by analyzing the proteome itself. This knowledge has yet to be incorporated into biomedical research as a guiding principle; neuroscience research is no exception.
For CNS disorder research, the advantages of nascent proteomics are far from being utilized, while existing and emerging technologies have already highlighted the feasibility.
This Research Topic targets studies focusing on molecular events from the onset through late stages of CNS disorders, as depicted by the characteristics of nascent proteomes. The ultimate goals are to identify the mechanisms that underlie the pathology of CNS disorders and to develop novel strategies for treatment or prevention.
This Research Topic welcomes CNS research on both acute and chronic disorders. Examples include, but are not limited to: acute disorders such as stroke, traumatic brain and spinal cord injury, epilepsy, infection; chronic or neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, amyotrophic lateral sclerosis, and substance abuse-associated disorders.
With an emphasis on nascent proteomics, this Research Topic also welcomes research using other approaches that assist our understanding of proteostasis in the CNS and its roles in the pathology of CNS disorders. They may include, but are not limited to: studies focusing on protein degradation, modifications, trafficking, spatial proteomics, or multi-Omics integration.
This Research Topic welcomes Original Research articles, Reviews (full or mini), Perspectives, Commentary, Methods, and Protocols.
CNS disorders either modeled in animals in vivo or simulated in cell cultures in vitro are within the scope of this Research Topic. Studies using data science approaches (e.g., by analyzing or re-analyzing omics data in public domains relevant to proteostasis in CNS disorders).
Articles addressing the following issues are sought encouraged: Molecular mechanisms underlying the establishment of stress-response neuroproteomics; nascent proteomic characterization of brain injury and modeled neuroprotection; balancing of protein biosynthesis and degradation in CNS stress response; nascent proteomes as a source for biomarkers of CNS disorders; brain region- or cell-type-specific changes; new technologies for labeling and analyzing nascent proteomes, and bioinformatic tools for integrating proteomic and transcriptomic data.
This Research Topic aims to provide a mechanistic view on how the Central Nervous System (CNS), in response to stresses, incurs phenotypical changes by regulated changes in the so-called nascent proteome –proteome consisting of newly synthesized proteins within a time window. Among many components or aspects of a proteome, the nascent proteome affords a description of response-in-action, when stressed cells attempt to maintain or reset the proteostasis. Both biosynthesis and degradation of proteins contribute to proteostasis. However, proteome-wide, the former has a higher degree of selectivity than the latter, especially when cellular conditions become deteriorating.
Principally, proteomes not only manifest the execution but also provide revisions of genomic instruction. The poor correlation between levels of proteins and gene transcripts (<0.4 on average) has long been noted. Thanks to the recent advancement in proteomic, transcriptomic, and bioinformatics technologies, this phenomenon is now recognized Ome-wide. This knowledge argues that characteristics of a proteome cannot be readily extrapolated from genomic or transcriptomic characterization, but by analyzing the proteome itself. This knowledge has yet to be incorporated into biomedical research as a guiding principle; neuroscience research is no exception.
For CNS disorder research, the advantages of nascent proteomics are far from being utilized, while existing and emerging technologies have already highlighted the feasibility.
This Research Topic targets studies focusing on molecular events from the onset through late stages of CNS disorders, as depicted by the characteristics of nascent proteomes. The ultimate goals are to identify the mechanisms that underlie the pathology of CNS disorders and to develop novel strategies for treatment or prevention.
This Research Topic welcomes CNS research on both acute and chronic disorders. Examples include, but are not limited to: acute disorders such as stroke, traumatic brain and spinal cord injury, epilepsy, infection; chronic or neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, amyotrophic lateral sclerosis, and substance abuse-associated disorders.
With an emphasis on nascent proteomics, this Research Topic also welcomes research using other approaches that assist our understanding of proteostasis in the CNS and its roles in the pathology of CNS disorders. They may include, but are not limited to: studies focusing on protein degradation, modifications, trafficking, spatial proteomics, or multi-Omics integration.
This Research Topic welcomes Original Research articles, Reviews (full or mini), Perspectives, Commentary, Methods, and Protocols.
CNS disorders either modeled in animals in vivo or simulated in cell cultures in vitro are within the scope of this Research Topic. Studies using data science approaches (e.g., by analyzing or re-analyzing omics data in public domains relevant to proteostasis in CNS disorders).
Articles addressing the following issues are sought encouraged: Molecular mechanisms underlying the establishment of stress-response neuroproteomics; nascent proteomic characterization of brain injury and modeled neuroprotection; balancing of protein biosynthesis and degradation in CNS stress response; nascent proteomes as a source for biomarkers of CNS disorders; brain region- or cell-type-specific changes; new technologies for labeling and analyzing nascent proteomes, and bioinformatic tools for integrating proteomic and transcriptomic data.