Despite advances in neonatal care, necrotising enterocolitis (NEC) continues to have a significantly high risk of mortality and morbidity, and with an increasing survival of more premature infants following successful resuscitation in the delivery rooms the population at risk of NEC is increasing. The majority of very preterm infants develop anaemia due to phlebotomy loss, and several of these babies are treated with blood transfusions. The resulting ischaemia, reperfusion, and inflammation underpin diseases that affect intestinal blood flow thereby triggering gut injury including NEC.
There is increasing interest in tissue biomarkers of gut injury in neonates, particularly those representing changes in intestinal wall barrier and permeability, as well as measurements of splanchnic blood flow and gut tissue oxygenation, to determine whether these could be useful biomarkers of gut injury.
This Research Topic is open to submissions that aim to address the following thematic areas:
1) Measurement of gut perfusion/tissue oxygenation using Near Infra-Red Spectroscopy (NIRS)
2) Measurement of gut perfusion/blood flow using Ultrasound Doppler
3) Controversies on blood transfusion, anemia and gut injury
4) Relationship between gut injury and cytokines
5) Tissue biomarkers of gut injury
6) Controversies around feeding during blood transfusion: epidemiological and gut perfusion perspective
7) Animal models gut perfusion and NEC
8) Cooling as a mode of management of NEC
9) Neonatal hypotension and NEC
10) Placental transfusion (delayed cord clamping) and NEC
11) Congenital heart disease and NEC.
Despite advances in neonatal care, necrotising enterocolitis (NEC) continues to have a significantly high risk of mortality and morbidity, and with an increasing survival of more premature infants following successful resuscitation in the delivery rooms the population at risk of NEC is increasing. The majority of very preterm infants develop anaemia due to phlebotomy loss, and several of these babies are treated with blood transfusions. The resulting ischaemia, reperfusion, and inflammation underpin diseases that affect intestinal blood flow thereby triggering gut injury including NEC.
There is increasing interest in tissue biomarkers of gut injury in neonates, particularly those representing changes in intestinal wall barrier and permeability, as well as measurements of splanchnic blood flow and gut tissue oxygenation, to determine whether these could be useful biomarkers of gut injury.
This Research Topic is open to submissions that aim to address the following thematic areas:
1) Measurement of gut perfusion/tissue oxygenation using Near Infra-Red Spectroscopy (NIRS)
2) Measurement of gut perfusion/blood flow using Ultrasound Doppler
3) Controversies on blood transfusion, anemia and gut injury
4) Relationship between gut injury and cytokines
5) Tissue biomarkers of gut injury
6) Controversies around feeding during blood transfusion: epidemiological and gut perfusion perspective
7) Animal models gut perfusion and NEC
8) Cooling as a mode of management of NEC
9) Neonatal hypotension and NEC
10) Placental transfusion (delayed cord clamping) and NEC
11) Congenital heart disease and NEC.
