The best IVF outcome for a patient is a healthy baby. How to make this outcome more of a reality for patients seeking IVF relies on selecting the most viable embryo for uterine transfer. This selection process has traditionally relied on morphology metrics, and more recently, genetic analysis of cells from the trophectoderm. Some efforts have even focused on using molecular markers from spent media and blastocoel fluid to assess the viability of the preimplantation embryo. However, there is still much that is unknown regarding early embryonic development and indicators of successful embryo transfer.
As technology has advanced, it has become easier than before to obtain a wide amount of information from a minimal amount of material. Techniques such as genomics, metabolomics, and proteomics have provided the perfect opportunity to explore the molecular and cellular events taking place within the preimplantation IVF embryo. Having a more thorough understanding of the changes taking place in this stage of development may allow for better use and interpretation of biomarkers of embryo viability, therefore increasing IVF success rates.
This research topic therefore has two aims. To further our understanding of how the pre-implantation embryo develops, and to further consider our current techniques used to evaluate embryo viability. By collecting articles on both themes, we may discover new potential molecular markers of embryo viability, thus increasing the success of IVF.
Submissions of all types will be considered, with the scope including (but not limited to):
• Epigenetic changes that take place during preimplantation embryo development
• Signaling pathways and metabolic processes that drive developmental processes in the preimplantation embryo
• Molecular markers that can be assessed during preimplantation development to predict uterine implantation success
• Insights into PGT-A results – what do they reveal about the genetic makeup of the preimplantation embryo? Does sampling the trophectoderm really provide the ploidy status for the whole embryo?
The best IVF outcome for a patient is a healthy baby. How to make this outcome more of a reality for patients seeking IVF relies on selecting the most viable embryo for uterine transfer. This selection process has traditionally relied on morphology metrics, and more recently, genetic analysis of cells from the trophectoderm. Some efforts have even focused on using molecular markers from spent media and blastocoel fluid to assess the viability of the preimplantation embryo. However, there is still much that is unknown regarding early embryonic development and indicators of successful embryo transfer.
As technology has advanced, it has become easier than before to obtain a wide amount of information from a minimal amount of material. Techniques such as genomics, metabolomics, and proteomics have provided the perfect opportunity to explore the molecular and cellular events taking place within the preimplantation IVF embryo. Having a more thorough understanding of the changes taking place in this stage of development may allow for better use and interpretation of biomarkers of embryo viability, therefore increasing IVF success rates.
This research topic therefore has two aims. To further our understanding of how the pre-implantation embryo develops, and to further consider our current techniques used to evaluate embryo viability. By collecting articles on both themes, we may discover new potential molecular markers of embryo viability, thus increasing the success of IVF.
Submissions of all types will be considered, with the scope including (but not limited to):
• Epigenetic changes that take place during preimplantation embryo development
• Signaling pathways and metabolic processes that drive developmental processes in the preimplantation embryo
• Molecular markers that can be assessed during preimplantation development to predict uterine implantation success
• Insights into PGT-A results – what do they reveal about the genetic makeup of the preimplantation embryo? Does sampling the trophectoderm really provide the ploidy status for the whole embryo?
