Fibrosis is a permanent scar tissue caused by the healing of wounds. The main pathological changes are increased fibrous connective tissue and decreased parenchymal cells. If the progress continues, it can lead to structural organ damage, functional decline, and even failure, seriously threatening human health and life. Tissue fibrosis is the leading cause of disability and death from many diseases worldwide. In particular, fibrosis can occur in the viscera, typically due to inflammation or damage. Therefore, fibrosis plays an essential role in the occurrence and development of significant organ diseases in the human body.
Following the previous topic '
Fibrosis in the Respiratory and Digestive Systems', this research topic aims to explore the pathogenesis and pathophysiological process of fibrotic diseases in heart, lung, pancreas, liver, kidney, and intestines, as well as clinical case diagnosis and treatment research, including genome-wide screening of disease-related functional genes, pathogenesis, screening of susceptible populations, early diagnosis, pathological analysis, screening of therapeutic targets, and new drugs development and related research.
In this research topic, we welcome original research articles and reviews, including but not limited to the following themes:
• Nature, etiology and pathophysiology of fibrotic disorders
• Biologically relevant aspects of the epidemiology, diagnosis, and treatment
• Drug discovery and development
• Basic and Clinical Pharmacology