Toxicity studies are very important for druggable compounds and natural products before they can be administered to humans. They are crucial in evaluating the safety of compounds and optimizing the dose for therapeutic effects. Preclinical toxicity studies are divided into many categories, including acute, sub-acute, chronic, cytotoxicity, teratogenicity and genotoxicity studies etc.
A new era of toxicity studies has emerged, which focuses on the pathways that lead to toxic effects. According to guidelines such as the Organization for Economic Cooperation and Development (OECD) or National Research Council (NRC), toxicity studies focused on signaling pathways are becoming increasingly important in drug discovery science. In this Research Topic, we want to place particular focus on studies centered on toxicity pathway exploration. We open this collection to gain insights into the current state of research on toxicity, addressing phenomena such as ligand behaviors, multifinality constraints, and the challenges and inconsistencies resulting from in silico, in vivo, in vitro and systematic studies of compounds and ligands. Recording and assessing the level of upregulation and downregulation of biomarkers, neurotransmitters, and proteins, which are all undesirable consequences, represents a key issue in toxicity research. While our special focus in isolation, characterization, synthesis, enzymatic studies and non-enzymatic studies i.e., molecular and behavior level preclinical studies. Understanding these and other factors including the role of biomarkers and neurotransmitters can lead to similarly sustainable goal engagement/ management for future inquiry. Although the isolation, characterization, synthesis, enzymatic studies and non-enzymatic studies of compounds are crucial in molecular and behavior level preclinical studies, gaining an understanding of the role of biomarkers and neurotransmitters and additional factors at play within the pathways that can lead to toxicity, is of great importance to further guide research.
Scientists show great interest in the discovery for novel and potent treatments against different diseases and safety is a key parameter in this process. Various compounds with druggable profiles are rejected in the early clinical phase due to a low safety profile. Understanding the elements that aid or hinder toxicity studies is therefore essential for successful compound/ligand translation into drug-like molecules. Although the medical field and pharmaceutical industry have been paying greater attention to this subject, and research has progressed significantly in recent decade, many unanswered questions remain. The goal of this research topic is to provide a platform for researchers to share their latest insights regarding toxicity profiling and their evaluation methodologies.
We open this topic to gain insights into the present state of toxicity research. Original Manuscripts, Review Articles, Commentaries, Communication Letters and Mini Reviews focusing on, but not limited to, any of the following themes are warmly welcome in this Research Topic:
• Toxicity studies on compounds having biological activities
• Pathways leading to toxicity
• Animal models for the validation of toxicity studies
• Molecular- and cellular-level toxicity studies
• Toxicity studies according to guidelines such as OECD or NRC
• Toxicity of natural and herbal products
• Teratogenicity studies
• Developmental toxicity
• Short- and long-duration toxicity studies
• Protective role of anti-oxidants against toxicity
Toxicity studies are very important for druggable compounds and natural products before they can be administered to humans. They are crucial in evaluating the safety of compounds and optimizing the dose for therapeutic effects. Preclinical toxicity studies are divided into many categories, including acute, sub-acute, chronic, cytotoxicity, teratogenicity and genotoxicity studies etc.
A new era of toxicity studies has emerged, which focuses on the pathways that lead to toxic effects. According to guidelines such as the Organization for Economic Cooperation and Development (OECD) or National Research Council (NRC), toxicity studies focused on signaling pathways are becoming increasingly important in drug discovery science. In this Research Topic, we want to place particular focus on studies centered on toxicity pathway exploration. We open this collection to gain insights into the current state of research on toxicity, addressing phenomena such as ligand behaviors, multifinality constraints, and the challenges and inconsistencies resulting from in silico, in vivo, in vitro and systematic studies of compounds and ligands. Recording and assessing the level of upregulation and downregulation of biomarkers, neurotransmitters, and proteins, which are all undesirable consequences, represents a key issue in toxicity research. While our special focus in isolation, characterization, synthesis, enzymatic studies and non-enzymatic studies i.e., molecular and behavior level preclinical studies. Understanding these and other factors including the role of biomarkers and neurotransmitters can lead to similarly sustainable goal engagement/ management for future inquiry. Although the isolation, characterization, synthesis, enzymatic studies and non-enzymatic studies of compounds are crucial in molecular and behavior level preclinical studies, gaining an understanding of the role of biomarkers and neurotransmitters and additional factors at play within the pathways that can lead to toxicity, is of great importance to further guide research.
Scientists show great interest in the discovery for novel and potent treatments against different diseases and safety is a key parameter in this process. Various compounds with druggable profiles are rejected in the early clinical phase due to a low safety profile. Understanding the elements that aid or hinder toxicity studies is therefore essential for successful compound/ligand translation into drug-like molecules. Although the medical field and pharmaceutical industry have been paying greater attention to this subject, and research has progressed significantly in recent decade, many unanswered questions remain. The goal of this research topic is to provide a platform for researchers to share their latest insights regarding toxicity profiling and their evaluation methodologies.
We open this topic to gain insights into the present state of toxicity research. Original Manuscripts, Review Articles, Commentaries, Communication Letters and Mini Reviews focusing on, but not limited to, any of the following themes are warmly welcome in this Research Topic:
• Toxicity studies on compounds having biological activities
• Pathways leading to toxicity
• Animal models for the validation of toxicity studies
• Molecular- and cellular-level toxicity studies
• Toxicity studies according to guidelines such as OECD or NRC
• Toxicity of natural and herbal products
• Teratogenicity studies
• Developmental toxicity
• Short- and long-duration toxicity studies
• Protective role of anti-oxidants against toxicity
