Inhibitory glycine receptors (GlyRs) containing the alpha1 and beta subunits are well known for their involvement in an inherited motor disorder (hyperekplexia) characterised by neonatal hypertonia and an exaggerated startle reflex.
However, it has recently emerged that other GlyR subtypes (e.g. those containing the alpha2, alpha3 and alpha4 subunits) may play more diverse biological roles. New animal models of glycinergic dysfunction have been reported in zebrafish (bandoneon, shocked), mice (cincinatti, Nmf11) and cows (CMD2). In addition, key studies on neurotransmitter transporters for glycine (GlyT1, GlyT2, VIAAT) have also revealed key roles for these presynaptic and glial proteins in health and disease.
Molecular modelling and structure/function studies have also provided key insights into allosteric signal transduction mechanisms and the diverse pharmacology of glycine receptors.
This Research Topic aims to bring together experts in the
field of glycinergic transmission, and encourage research articles or topical reviews to provide an up-to-date perspective on the insights into receptor, transporter and synaptic function that can be gained by the study of
glycinergic transmission.
Inhibitory glycine receptors (GlyRs) containing the alpha1 and beta subunits are well known for their involvement in an inherited motor disorder (hyperekplexia) characterised by neonatal hypertonia and an exaggerated startle reflex.
However, it has recently emerged that other GlyR subtypes (e.g. those containing the alpha2, alpha3 and alpha4 subunits) may play more diverse biological roles. New animal models of glycinergic dysfunction have been reported in zebrafish (bandoneon, shocked), mice (cincinatti, Nmf11) and cows (CMD2). In addition, key studies on neurotransmitter transporters for glycine (GlyT1, GlyT2, VIAAT) have also revealed key roles for these presynaptic and glial proteins in health and disease.
Molecular modelling and structure/function studies have also provided key insights into allosteric signal transduction mechanisms and the diverse pharmacology of glycine receptors.
This Research Topic aims to bring together experts in the
field of glycinergic transmission, and encourage research articles or topical reviews to provide an up-to-date perspective on the insights into receptor, transporter and synaptic function that can be gained by the study of
glycinergic transmission.
