Frailty is a multidisciplinary condition with increased vulnerability to stressors, common in older adults. Frail older adults have a higher risk of adverse outcomes such as cognitive and physical impairment. Aging leads to high oxidative stress caused by the accumulation of reactive oxygen and nitrogen species. Moreover, frail older adults suffer from many comorbidities, including cardiovascular and metabolic diseases (e.g. hypertension, heart failure, diabetes), which further increase oxidative stress. In the effort to manage frail patients, many tools, scales, and test have been developed. Nowadays, there is no reliable test and/or blood analysis investigating the role/impact of oxidative stress and mitochondrial function.
Aging is increasing steeply as life expectancy is advancing. Aging is related to frailty because older adults have a higher risk to lose their independency compared to younger people. Cognitive and physical impairment are common in frailty, with or without dementia. Moreover, frail older adults suffer from many comorbidities, particularly cardiovascular and metabolic diseases, including hypertension, heart failure, diabetes, and metabolic syndrome, which increase the risk of oxidative stress. We aim to improve the diagnostic and therapeutic management of frailty. We believe that “the oxidative stress theory of aging” should be one of the best actors driving functional decline and frailty. Also, mitochondrial dysfunction should be involved/linked in aging associated inflammation and oxidative stress. Hence, in this Research Topic we welcome original studies and reviews investigating the relationships between frailty and oxidative stress in older adults.
Hereafter, we summarize the aim and scope for the authors:
• Oxidative Stress and Mitochondrial Dysfunction in Frail Older Adults
• Hypertension, Diabetes and Oxidative Stress in Frailty: Role of Endothelium
• Link Between Cognitive and Physical Impairment in Frailty
• Cognitive Frailty
• New Diagnostic and Therapeutic Tools in Frailty
• Targets to Reverse Frailty and Cognitive Frailty
• Molecular Pathways involved in Frailty
Frailty is a multidisciplinary condition with increased vulnerability to stressors, common in older adults. Frail older adults have a higher risk of adverse outcomes such as cognitive and physical impairment. Aging leads to high oxidative stress caused by the accumulation of reactive oxygen and nitrogen species. Moreover, frail older adults suffer from many comorbidities, including cardiovascular and metabolic diseases (e.g. hypertension, heart failure, diabetes), which further increase oxidative stress. In the effort to manage frail patients, many tools, scales, and test have been developed. Nowadays, there is no reliable test and/or blood analysis investigating the role/impact of oxidative stress and mitochondrial function.
Aging is increasing steeply as life expectancy is advancing. Aging is related to frailty because older adults have a higher risk to lose their independency compared to younger people. Cognitive and physical impairment are common in frailty, with or without dementia. Moreover, frail older adults suffer from many comorbidities, particularly cardiovascular and metabolic diseases, including hypertension, heart failure, diabetes, and metabolic syndrome, which increase the risk of oxidative stress. We aim to improve the diagnostic and therapeutic management of frailty. We believe that “the oxidative stress theory of aging” should be one of the best actors driving functional decline and frailty. Also, mitochondrial dysfunction should be involved/linked in aging associated inflammation and oxidative stress. Hence, in this Research Topic we welcome original studies and reviews investigating the relationships between frailty and oxidative stress in older adults.
Hereafter, we summarize the aim and scope for the authors:
• Oxidative Stress and Mitochondrial Dysfunction in Frail Older Adults
• Hypertension, Diabetes and Oxidative Stress in Frailty: Role of Endothelium
• Link Between Cognitive and Physical Impairment in Frailty
• Cognitive Frailty
• New Diagnostic and Therapeutic Tools in Frailty
• Targets to Reverse Frailty and Cognitive Frailty
• Molecular Pathways involved in Frailty