Research Topic Highlights
This article collection focuses on aging-related diseases, frailty, and metabolic and cardiovascular conditions in older adults, particularly emphasizing pathological mechanisms, clinical implications, and risk stratification strategies. The articles collectively address the roles of mitochondrial dysfunction and oxidative stress in age-related retinal diseases, highlighting mitochondrial dynamics and potential therapeutic interventions for retinal pigment epithelium aging and degeneration. Another key focus is the role of specific biomarkers, such as miRNA-34a, in diabetic frailty, their regulation of oxidative stress, and potential as therapeutic targets. Evaluations of cardiovascular risks associated with diabetes treatments, specifically GLP-1 receptor agonists, suggest no increased arrhythmia risk but show reduced incidences of hypoglycemia and pneumonia. Further studies discuss the relationship between severe non-alcoholic fatty liver disease (NAFLD), hypertension, and increased cardiovascular event risks. Additionally, articles investigate the clinical and prognostic relationships between frailty, comorbidities, medication burden, and atrial fibrillation. Lastly, social frailty in the context of cardiovascular and cerebrovascular diseases (CCVD) among older adults is analyzed, demonstrating regional variations and associations with demographic, health status, and living conditions, emphasizing the importance of assessing social health dimensions in geriatric populations.
Context and Scope
Frailty is a multidisciplinary condition with increased vulnerability to stressors, common in older adults. Frail older adults have a higher risk of adverse outcomes such as cognitive and physical impairment. Aging leads to high oxidative stress caused by the accumulation of reactive oxygen and nitrogen species. Moreover, frail older adults suffer from many comorbidities, including cardiovascular and metabolic diseases (e.g. hypertension, heart failure, diabetes), which further increase oxidative stress. In the effort to manage frail patients, many tools, scales, and test have been developed. Nowadays, there is no reliable test and/or blood analysis investigating the role/impact of oxidative stress and mitochondrial function.
Aging is increasing steeply as life expectancy is advancing. Aging is related to frailty because older adults have a higher risk to lose their independency compared to younger people. Cognitive and physical impairment are common in frailty, with or without dementia. Moreover, frail older adults suffer from many comorbidities, particularly cardiovascular and metabolic diseases, including hypertension, heart failure, diabetes, and metabolic syndrome, which increase the risk of oxidative stress. We aim to improve the diagnostic and therapeutic management of frailty. We believe that “the oxidative stress theory of aging” should be one of the best actors driving functional decline and frailty. Also, mitochondrial dysfunction should be involved/linked in aging associated inflammation and oxidative stress. Hence, in this Research Topic we welcome original studies and reviews investigating the relationships between frailty and oxidative stress in older adults.
Hereafter, we summarize the aim and scope for the authors:
• Oxidative Stress and Mitochondrial Dysfunction in Frail Older Adults
• Hypertension, Diabetes and Oxidative Stress in Frailty: Role of Endothelium
• Link Between Cognitive and Physical Impairment in Frailty
• Cognitive Frailty
• New Diagnostic and Therapeutic Tools in Frailty
• Targets to Reverse Frailty and Cognitive Frailty
• Molecular Pathways involved in Frailty
Research Topic Highlights
This article collection focuses on aging-related diseases, frailty, and metabolic and cardiovascular conditions in older adults, particularly emphasizing pathological mechanisms, clinical implications, and risk stratification strategies. The articles collectively address the roles of mitochondrial dysfunction and oxidative stress in age-related retinal diseases, highlighting mitochondrial dynamics and potential therapeutic interventions for retinal pigment epithelium aging and degeneration. Another key focus is the role of specific biomarkers, such as miRNA-34a, in diabetic frailty, their regulation of oxidative stress, and potential as therapeutic targets. Evaluations of cardiovascular risks associated with diabetes treatments, specifically GLP-1 receptor agonists, suggest no increased arrhythmia risk but show reduced incidences of hypoglycemia and pneumonia. Further studies discuss the relationship between severe non-alcoholic fatty liver disease (NAFLD), hypertension, and increased cardiovascular event risks. Additionally, articles investigate the clinical and prognostic relationships between frailty, comorbidities, medication burden, and atrial fibrillation. Lastly, social frailty in the context of cardiovascular and cerebrovascular diseases (CCVD) among older adults is analyzed, demonstrating regional variations and associations with demographic, health status, and living conditions, emphasizing the importance of assessing social health dimensions in geriatric populations.
Context and Scope
Frailty is a multidisciplinary condition with increased vulnerability to stressors, common in older adults. Frail older adults have a higher risk of adverse outcomes such as cognitive and physical impairment. Aging leads to high oxidative stress caused by the accumulation of reactive oxygen and nitrogen species. Moreover, frail older adults suffer from many comorbidities, including cardiovascular and metabolic diseases (e.g. hypertension, heart failure, diabetes), which further increase oxidative stress. In the effort to manage frail patients, many tools, scales, and test have been developed. Nowadays, there is no reliable test and/or blood analysis investigating the role/impact of oxidative stress and mitochondrial function.
Aging is increasing steeply as life expectancy is advancing. Aging is related to frailty because older adults have a higher risk to lose their independency compared to younger people. Cognitive and physical impairment are common in frailty, with or without dementia. Moreover, frail older adults suffer from many comorbidities, particularly cardiovascular and metabolic diseases, including hypertension, heart failure, diabetes, and metabolic syndrome, which increase the risk of oxidative stress. We aim to improve the diagnostic and therapeutic management of frailty. We believe that “the oxidative stress theory of aging” should be one of the best actors driving functional decline and frailty. Also, mitochondrial dysfunction should be involved/linked in aging associated inflammation and oxidative stress. Hence, in this Research Topic we welcome original studies and reviews investigating the relationships between frailty and oxidative stress in older adults.
Hereafter, we summarize the aim and scope for the authors:
• Oxidative Stress and Mitochondrial Dysfunction in Frail Older Adults
• Hypertension, Diabetes and Oxidative Stress in Frailty: Role of Endothelium
• Link Between Cognitive and Physical Impairment in Frailty
• Cognitive Frailty
• New Diagnostic and Therapeutic Tools in Frailty
• Targets to Reverse Frailty and Cognitive Frailty
• Molecular Pathways involved in Frailty