Large animals show similarities in many physical and pathological characteristics with humans. Therefore, large animal models have advantages in developmental and medical research. For example, generation organs suitable for the human being from large animals is emerging as a potential strategy to cure patients suffering various debilitating and fatal diseases. Thus, investigation on the spermatogenesis, oogenesis, embryogenesis and developmental process would largely contribute to the application of large animals in medical research and serve as a potential reference for the embryology of human beings. In addition, it is crucial to exploit the genetic and epigenetic landscape of sperm, egg, zygote, embryo and fetus.
Furthermore, establishing pluripotent stem cells and examining their pluripotency is also critical for the application in disease modeling and therapy. In recent years, significant progress in gene-editing techniques has been achieved, especially for the coming out of CRISPR/Cas9 mediated gene modification strategies. Various types of human disease have been studied using porcine, cow, monkey, sheep and rabbit models, including Alzheimer's disease, Huntington's Disease, amyotrophic lateral sclerosis and cancer. Studies in the recent decade have gathered novel implications for human physical and pathological progress by using these models. Generally, it is meaningful to focus on developmental and medical studies using large animal models.
The Research Topic aims to welcome Original Research and Review covering the latest and current research on the large animal model. In addition, articles regarding the embryonic, developmental and medical study on large animals are welcome.
Areas in the Research Topic may include, but are not limited to:
- Molecular and cellular mechanism during embryonic development;
- Profile of DNA methylation, histone modification, non-coding RNA and chromatin remodeling in embryogenesis and disease modeling;
- Establishment and application of pluripotent stem cells;
- Mimic, investigation and preliminary treatment on human disease in a large animal model;
- Developing gene-editing technique or combination with pharmacology, nanoparticle delivery system, or imaging technique for more extensive animal study.
Large animals show similarities in many physical and pathological characteristics with humans. Therefore, large animal models have advantages in developmental and medical research. For example, generation organs suitable for the human being from large animals is emerging as a potential strategy to cure patients suffering various debilitating and fatal diseases. Thus, investigation on the spermatogenesis, oogenesis, embryogenesis and developmental process would largely contribute to the application of large animals in medical research and serve as a potential reference for the embryology of human beings. In addition, it is crucial to exploit the genetic and epigenetic landscape of sperm, egg, zygote, embryo and fetus.
Furthermore, establishing pluripotent stem cells and examining their pluripotency is also critical for the application in disease modeling and therapy. In recent years, significant progress in gene-editing techniques has been achieved, especially for the coming out of CRISPR/Cas9 mediated gene modification strategies. Various types of human disease have been studied using porcine, cow, monkey, sheep and rabbit models, including Alzheimer's disease, Huntington's Disease, amyotrophic lateral sclerosis and cancer. Studies in the recent decade have gathered novel implications for human physical and pathological progress by using these models. Generally, it is meaningful to focus on developmental and medical studies using large animal models.
The Research Topic aims to welcome Original Research and Review covering the latest and current research on the large animal model. In addition, articles regarding the embryonic, developmental and medical study on large animals are welcome.
Areas in the Research Topic may include, but are not limited to:
- Molecular and cellular mechanism during embryonic development;
- Profile of DNA methylation, histone modification, non-coding RNA and chromatin remodeling in embryogenesis and disease modeling;
- Establishment and application of pluripotent stem cells;
- Mimic, investigation and preliminary treatment on human disease in a large animal model;
- Developing gene-editing technique or combination with pharmacology, nanoparticle delivery system, or imaging technique for more extensive animal study.
