Flavonoids are a diverse group of phytochemicals that are widely found in fruits and vegetables. The main dietary source of flavonoids includes berry fruits, tea, citrus, apples, colored grain, etc. Recently, a series of techniques have been established to extract and identify natural flavonoids from plant-based sources. However, those methods are time-consuming, laborious, and not cost-effective. In addition, a lot of natural flavonoids cannot be efficiently extracted. Many plant-based resources are still underexploited for natural flavonoids extraction and identification. Therefore, it is essential to develop new techniques for flavonoids extraction and to construct high-throughput screening models searching for bioactive flavonoids from plant-based resources.
This Research Topic aims to provide the latest research information about the bioavailability, absorption, and metabolism mechanism of natural flavonoids. Accumulating evidence indicates the health-promoting effect of flavonoids against inflammation, oxidative stress, lipid and glucose metabolism disorders and aging. To elucidate the health benefits of natural flavonoids, it is important to understand the concentration and forms presented in plasma and tissues after dietary ingestion of flavonoids. However, the bioavailability, absorption, and metabolism mechanism of natural flavonoids in the body are complicated and still deserve further investigation.
This Research Topic is also interested in the latest findings on the targeted delivery of flavonoids. Increasing evidence indicates that dietary flavonoids exhibited low accessibility and bioavailability in the gastrointestinal tract, which weakens the health benefits of flavonoids. Therefore, targeted delivery of natural flavonoids by nanoparticles or self-assembly would potentially promote the bioavailability and bioactivity of natural flavonoids. All the information on this Research Topic would contribute to a better understanding of the health benefits of natural flavonoids.
We welcome manuscripts of different types (e.g., Original Research, Perspectives, Mini Reviews, Commentaries and Opinion papers) from, but not limited to, the following themes:
• New techniques or methods for extraction and identification of natural flavonoids from plant-based resources.
• Construction of high-throughput screening models searching for bioactive flavonoids from plant-based resources.
• The transformation mechanism of natural flavonoids during food storage and processing.
• Elucidating the bioavailability, absorption, and metabolism mechanisms of natural flavonoids in vivo using novel techniques.
• The bioactivity and nutritional efficacy of natural flavonoids on oxidative stress, glucose and lipid metabolism, immunomodulation, aging, etc. and their underlying molecular mechanisms.
• Developing targeted delivery systems to improve the bioavailability and biological activity of natural flavonoids.
Flavonoids are a diverse group of phytochemicals that are widely found in fruits and vegetables. The main dietary source of flavonoids includes berry fruits, tea, citrus, apples, colored grain, etc. Recently, a series of techniques have been established to extract and identify natural flavonoids from plant-based sources. However, those methods are time-consuming, laborious, and not cost-effective. In addition, a lot of natural flavonoids cannot be efficiently extracted. Many plant-based resources are still underexploited for natural flavonoids extraction and identification. Therefore, it is essential to develop new techniques for flavonoids extraction and to construct high-throughput screening models searching for bioactive flavonoids from plant-based resources.
This Research Topic aims to provide the latest research information about the bioavailability, absorption, and metabolism mechanism of natural flavonoids. Accumulating evidence indicates the health-promoting effect of flavonoids against inflammation, oxidative stress, lipid and glucose metabolism disorders and aging. To elucidate the health benefits of natural flavonoids, it is important to understand the concentration and forms presented in plasma and tissues after dietary ingestion of flavonoids. However, the bioavailability, absorption, and metabolism mechanism of natural flavonoids in the body are complicated and still deserve further investigation.
This Research Topic is also interested in the latest findings on the targeted delivery of flavonoids. Increasing evidence indicates that dietary flavonoids exhibited low accessibility and bioavailability in the gastrointestinal tract, which weakens the health benefits of flavonoids. Therefore, targeted delivery of natural flavonoids by nanoparticles or self-assembly would potentially promote the bioavailability and bioactivity of natural flavonoids. All the information on this Research Topic would contribute to a better understanding of the health benefits of natural flavonoids.
We welcome manuscripts of different types (e.g., Original Research, Perspectives, Mini Reviews, Commentaries and Opinion papers) from, but not limited to, the following themes:
• New techniques or methods for extraction and identification of natural flavonoids from plant-based resources.
• Construction of high-throughput screening models searching for bioactive flavonoids from plant-based resources.
• The transformation mechanism of natural flavonoids during food storage and processing.
• Elucidating the bioavailability, absorption, and metabolism mechanisms of natural flavonoids in vivo using novel techniques.
• The bioactivity and nutritional efficacy of natural flavonoids on oxidative stress, glucose and lipid metabolism, immunomodulation, aging, etc. and their underlying molecular mechanisms.
• Developing targeted delivery systems to improve the bioavailability and biological activity of natural flavonoids.
